GO Report

Basic Info
ID GO:0007268
Name synaptic transmission
Type biological process
No. of Genes in BDgene  116
Source Pathway by PBA

PBA Result
Pathway Name in Paper Source Reference Data Set Tool Result Parameters Result Link
GO: 0007268: synaptic transmission PBA paper Askland, K.,2009 NIMH Fisher's exact test Results given for gene sets with P < 0.01 from the NIMH PBA-BP data

GO related genes in BDgene (count: 116)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend) Evidence[PMID]
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 3(2/1/0) IBA
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1p36.1 1(0/1/0) TAS
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17p13.1 1(1/0/0) TAS
SSTR1 somatostatin receptor 1 14q13 1(1/0/0) IBA
SST somatostatin 3q28 1(0/1/0) TAS[9437026]
DRD4 dopamine receptor D4 11p15.5 13(1/12/0) IBA
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 11q23.1 2(1/1/0) TAS[9950429]
GRIA1 glutamate receptor, ionotropic, AMPA 1 5q33 2(2/0/0) TAS
NRXN1 neurexin 1 2p16.3 1(1/0/0) ISS
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 2(0/2/0) TAS
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1q21.3 7(1/6/0) TAS
CHAT choline O-acetyltransferase 10q11.2 1(0/1/0) TAS
GRM3 glutamate receptor, metabotropic 3 7q21.1-q21.2 7(3/4/0) TAS[8840013]
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 20q13.33 1(1/0/0) TAS
DLG3 discs, large homolog 3 (Drosophila) Xq13.1 1(0/1/0) IBA; TAS
DRD5 dopamine receptor D5 4p16.1 2(0/2/0) NAS[7727453]
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 5q34 1(1/0/0) TAS
GRIP1 glutamate receptor interacting protein 1 12q13.13 1(1/0/0) TAS
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10q21-q24 2(0/2/0) IEA
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1q21.3 1(1/0/0) TAS
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 10q25 1(1/0/0) TAS[15217342]
GRIA3 glutamate receptor, ionotropic, AMPA 3 Xq25 1(0/1/0) TAS
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 22q13.1 3(3/0/0) TAS
MAOA monoamine oxidase A Xp11.4-p11.3 21(10/11/0) TAS
PICK1 protein interacting with PRKCA 1 22q13.1 1(0/1/0) TAS
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 15q24 3(1/2/0) TAS
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 5q34 2(1/1/0) TAS
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2q31 2(1/1/0) TAS
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 5q13 1(0/0/1) TAS
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3p21.31 1(0/1/0) TAS
GRM7 glutamate receptor, metabotropic 7 3p26-p25 3(2/1/0) IDA[9473604]
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 4p14 2(0/2/0) TAS
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 5q34 1(0/1/0) TAS
GRIK4 glutamate receptor, ionotropic, kainate 4 11q23.3 2(1/1/0) TAS
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 6q15 1(1/0/0) TAS
CARTPT CART prepropeptide 5q13.2 1(0/1/0) IEA
ADCY9 adenylate cyclase 9 16p13.3 2(1/1/0) TAS
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 12p13 2(1/1/0) TAS
GRM2 glutamate receptor, metabotropic 2 3p21.2 1(0/1/0) TAS[7620613]
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1q25.3 1(1/0/0) IBA; TAS
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 12q13 1(0/0/1) IBA; TAS
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 3q26.32 1(1/0/0) IBA; TAS
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 4p12 2(2/0/0) TAS
GRIK3 glutamate receptor, ionotropic, kainate 3 1p34.3 1(1/0/0) TAS
NPFFR2 neuropeptide FF receptor 2 4q21 1(0/1/0) IBA
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 20(17/3/0) IEA
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 4p12 3(2/0/1) TAS
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 15q24 2(1/1/0) TAS
CREB1 cAMP responsive element binding protein 1 2q34 2(1/1/0) TAS
SYN2 synapsin II 3p25.2 1(0/1/0) TAS[8964517]
GRM4 glutamate receptor, metabotropic 4 6p21.3 2(2/0/0) IEA
NEFL neurofilament, light polypeptide 8p21.2 1(0/1/0) TAS
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 Xq28 3(1/2/0) TAS
MBP myelin basic protein 18q23 1(1/0/0) TAS[2434243]
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 9p24 1(1/0/0) TAS[7521911]
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 8p21 3(0/3/0) TAS
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 11p13-p12 1(1/0/0) TAS[7521911]
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 15q24 3(2/1/0) TAS[9009220]
PNOC prepronociceptin 8p21 1(0/1/0) IEA
SYPL1 synaptophysin-like 1 7q22.2 1(1/0/0) TAS[8034131]
FGF12 fibroblast growth factor 12 3q28 1(0/1/0) IEA
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 3(1/2/0) TAS[8522988]
NPTX1 neuronal pentraxin I 17q25.3 2(1/1/0) TAS[8884281]
NCALD neurocalcin delta 8q22.3 1(0/1/0) TAS
NRXN3 neurexin 3 14q31 2(2/0/0) IEA
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 11q13.3 1(1/0/0) TAS
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 12q24.12 3(3/0/0) TAS
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 3p12 1(1/0/0) TAS[8380639]
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 9q22.1-q22.3 2(0/2/0) TAS
TSPO translocator protein (18kDa) 22q13.3 3(1/2/0) IEA
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 9q34 1(1/0/0) IBA; TAS
PMCH pro-melanin-concentrating hormone 12q23.2 1(1/0/0) IEA
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 1(1/0/0) TAS
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 2q24.3 3(2/0/1) TAS
ADCY8 adenylate cyclase 8 (brain) 8q24 4(2/1/1) TAS
GRIK2 glutamate receptor, ionotropic, kainate 2 6q16.3 3(1/1/1) TAS
COMT catechol-O-methyltransferase 22q11.21 28(14/14/0) TAS
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 15q12 3(1/2/0) TAS
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 15q12 1(0/1/0) TAS
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 11(5/6/0) TAS
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p13.1 8(4/4/0) TAS
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2q31.1 2(0/1/1) TAS
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 3q11.2 1(1/0/0) NAS[10542332]; TAS
ADCY2 adenylate cyclase 2 (brain) 5p15.3 2(1/1/0) TAS
SSTR5 somatostatin receptor 5 16p13.3 2(1/1/0) IBA
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 9q34.3 3(2/1/0) TAS
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1p36.3-p34.3 1(0/1/0) IEA
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 8p11.21 3(1/2/0) TAS
DLG2 discs, large homolog 2 (Drosophila) 11q21 3(1/1/1) IBA
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 7(4/3/0) TAS[9241279]
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 16q12.2 2(0/2/0) TAS[2008212]
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 19q13.33 1(1/0/0) TAS
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 11q23.1-q23.2 2(1/1/0) TAS[7565620]
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 11p15.1 1(0/1/0) TAS[9845349]
KCNK10 potassium channel, two pore domain subfamily K, member 10 14q31 1(1/0/0) TAS
HCRTR1 hypocretin (orexin) receptor 1 1p33 1(1/0/0) TAS[9491897]
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 10p13-p11.2 1(0/1/0) TAS
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5q31-q33 2(1/1/0) IEA
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9q34 3(1/2/0) TAS[2880016]
GRIK5 glutamate receptor, ionotropic, kainate 5 19q13.2 2(1/0/1) TAS
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 5q32 2(1/1/0) TAS
DRD3 dopamine receptor D3 3q13.3 19(4/15/0) IBA
CRH corticotropin releasing hormone 8q13 2(1/1/0) TAS[7477348]
DLG1 discs, large homolog 1 (Drosophila) 3q29 2(1/1/0) IBA; TAS
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 4(2/2/0) TAS
SNCG synuclein, gamma (breast cancer-specific protein 1) 10q23.2-q23.3 1(0/1/0) IEA
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 8q24 4(3/0/1) TAS
NRXN2 neurexin 2 11q13 1(1/0/0) IEA; ISS
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 6q14-q15 1(0/1/0) IEA
HCRTR2 hypocretin (orexin) receptor 2 6p12.1 1(1/0/0) TAS[9491897]
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 20q13.33 1(1/0/0) NAS[7550350]; TAS
SNAP25 synaptosomal-associated protein, 25kDa 20p12-p11.2 2(2/0/0) NAS[8760387]; TAS
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 7q31 1(1/0/0) TAS[11102480]
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 8p22 1(0/1/0) TAS
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 22(7/15/0) TAS[9109547]
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 15q12 6(6/0/0) TAS