Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PRKACB
Symbol Alias	PKACb
Approved Name	protein kinase, cAMP-dependent, catalytic, beta
Location	1p36.1
Position	chr1:84078062-84238498, 1
External Links	HGNC: 9381 Entrez Gene: 5567 Ensembl: ENSG00000142875 UCSC: uc001djl.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McDonald, M. L.,2012	SNP: rs600674	None of the association tests of the tagSNPs with either BPD I or BPD II reached genome-wide significance (P < 5E-08).	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 42)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	TAS	49
GO:0007268	synaptic transmission	biological process	TAS	116
GO:0005886	plasma membrane	cellular component	IEA	360

GO terms by database search (count: 39)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001843	neural tube closure	biological process	IEA	8
GO:0005829	cytosol	cellular component	TAS	223
GO:0007165	signal transduction	biological process	TAS	136
GO:0005524	ATP binding	molecular function	IDA[12420224]	118
GO:0005515	protein binding	molecular function	IPI[21880142]	563
GO:0051447	negative regulation of meiotic cell cycle	biological process	IEA	1
GO:0005813	centrosome	cellular component	IDA[21399614]	34
GO:0000287	magnesium ion binding	molecular function	IDA[12420224]	11
GO:0034199	activation of protein kinase A activity	biological process	TAS	5
GO:0005975	carbohydrate metabolic process	biological process	TAS	12
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[12420224]	10
GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	biological process	IEA	1
GO:0003091	renal water homeostasis	biological process	TAS	9
GO:0007596	blood coagulation	biological process	TAS	44
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	21
GO:0006006	glucose metabolic process	biological process	TAS	10
GO:0035556	intracellular signal transduction	biological process	TAS	38
GO:0071377	cellular response to glucagon stimulus	biological process	TAS	7
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0019433	triglyceride catabolic process	biological process	TAS	3
GO:0009405	pathogenesis	biological process	TAS	13
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0050796	regulation of insulin secretion	biological process	TAS	24
GO:0007202	activation of phospholipase C activity	biological process	TAS	15
GO:0006468	protein phosphorylation	biological process	IDA[12420224]	42
GO:0006094	gluconeogenesis	biological process	TAS	4
GO:0070613	regulation of protein processing	biological process	IEA	3
GO:0097338	response to clozapine	biological process	IEA	1
GO:0006833	water transport	biological process	TAS	9
GO:0031625	ubiquitin protein ligase binding	molecular function	IDA[21423175]	25
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	22
GO:0005952	cAMP-dependent protein kinase complex	cellular component	TAS[12420224]	2
GO:0004691	cAMP-dependent protein kinase activity	molecular function	IDA[12420224]	1
GO:0097546	ciliary base	cellular component	TAS	6
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	50
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0006112	energy reserve metabolic process	biological process	TAS	19

Gene related KEGG pathways (count: 13)

KEGG pathways by PBA (count: 5)

ID	Name	No. of Genes in BDgene
hsa04540	Gap junction	15
hsa04010	MAPK signaling pathway	39
hsa04720	Long-term potentiation	13
hsa04020	Calcium signaling pathway	53
hsa04210	Apoptosis	12

KEGG pathways by database search (count: 8)

ID	Name	No. of Genes in BDgene
hsa05110	Vibrio cholerae infection	9
hsa04742	Taste transduction	7
hsa04740	Olfactory transduction	11
hsa04310	Wnt signaling pathway	20
hsa04340	Hedgehog signaling pathway	8
hsa04916	Melanogenesis	16
hsa04912	GnRH signaling pathway	17
hsa04910	Insulin signaling pathway	10

Gene related BioCarta pathways (count: 22)

BioCarta pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
badPathway	Regulation of BAD phosphorylation	9

BioCarta pathways by database search (count: 21)

ID	Name	No. of Genes in BDgene
shhPathway	Sonic Hedgehog (Shh) Pathway	5
pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	12
mCalpainPathway	mCalpain and friends in Cell motility	3
nfatPathway	NFAT and Hypertrophy of the heart (Transcription in the broken heart)	11
akap95Pathway	AKAP95 role in mitosis and chromosome dynamics	1
carm1Pathway	Transcription Regulation by Methyltransferase of CARM1	4
dreampathway	Repression of Pain Sensation by the Transcriptional Regulator DREAM	4
agpcrPathway	Attenuation of GPCR Signaling	3
mPRPathway	How Progesterone Initiates Oocyte Membrane	3
igf1rPathway	Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation	5
crebPathway	Transcription factor CREB and its extracellular signals	8
CSKPathway	Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor	4
akap13Pathway	Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation	2
no1Pathway	Actions of Nitric Oxide in the Heart	9
ck1Pathway	Regulation of ck1/cdk5 by type 1 glutamate receptors	6
GATA3pathway	GATA3 participate in activating the Th2 cytokine genes expression	2
vipPathway	Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells	9
plcePathway	Phospholipase C-epsilon pathway	4
stathminPathway	Stathmin and breast cancer resistance to antimicrotubule agents	3
gpcrPathway	Signaling Pathway from G-Protein Families	7
akapCentrosomePathway	Protein Kinase A at the Centrosome	3

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PRKACB	PKIA	YES	in vitro	12798691
PRKACB	NGFR	NO	in vitro;in vivo;yeast 2-hybrid	12682012

Related other genetic factors

Gene related SNPs (count: 3)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs600674	chr1:84235568 - 84235568(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)

LD-proxies (count: 2)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs2389717		chr1:84228559 - 84228559(1)	intron_variant
rs1027694		chr1:84239902 - 84239902(1)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
1p31.1-p22.1	chr1:69300000-94300000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)
1p31.1	chr1:69300000-84400000	0

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:84078062..84238498 View in gBrowse