Gene Report

Basic Info
Approved Symbol CSF2RB
Previous Symbol IL3RB
Symbol Alias IL5RB, CD131
Approved Name colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Location 22q12.3
Position chr22:36913628-36940449, 1
External Links HGNC: 2436
Entrez Gene: 1439
Ensembl: ENSG00000100368
UCSC: uc003aqa.4
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Chen, P.,2011 SNP: rs11705394, rs1801117, rs2072707, rs2284031, rs4821565, rs738149, rs909486
Haplotype: rs2284031 - rs909486 - rs738149(C-T-A), rs2284031 - rs909486 - rs738149(C-T-G), rs2284031 - rs909486 - rs738149(T-C-A), rs2284031 - rs909486 - rs738149(T-C-G)
No positive signal in this gene was observed for BPAD. Negative Comment on Study
Moskvina, V.,2009 In BP:Smallest P-value per gene=0.00035, Product of P truncation <=0.01=0.0094, Product of P truncation <=0.001=0.00119. It showed evidence for association with BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 3)

GO terms by database search (count: 10)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 2)

BioCarta pathways by database search (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 24)

Related other genetic factors
Gene related SNPs (count: 37)

Literature-origin SNPs (count: 7)

LD-proxies (count: 30)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr22:36913628..36940449 View in gBrowse
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