Gene Report

Basic Info
Approved Symbol ALOX12
Symbol Alias 12S-LOX
Approved Name arachidonate 12-lipoxygenase
Name Alias platelet 12-LOX
Location 17p13.1
Position chr17:6996065-7010736, 1
External Links HGNC: 429
Entrez Gene: 239
Ensembl: ENSG00000108839
UCSC: uc002gdx.4
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fridman, C.,2003 Other variant: ALOX12_R261Q An increased presence of allele A among patients was found, suggesting an association of this polymorphism with the BPD in this Brazilian sample. Positive Comment on Study
Yosifova, A.,2009 SNP: rs1126667 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 44)

GO terms by PBA (count: 1)

GO terms by database search (count: 43)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Related other genetic factors
Gene related SNPs (count: 8)

Literature-origin SNPs (count: 1)

LD-proxies (count: 7)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr17:6996065..7010736 View in gBrowse
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