Gene Report

Basic Info
Approved Symbol CHRNB1
Previous Symbol CHRNB
Approved Name cholinergic receptor, nicotinic, beta 1 (muscle)
Previous Name cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
Name Alias acetylcholine receptor, nicotinic, beta 1 (muscle)
Location 17p13.1
Position chr17:7445061-7457707, 1
External Links HGNC: 1961
Entrez Gene: 1140
Ensembl: ENSG00000170175
UCSC: uc002ghb.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Shi, J., 2007 SNP: rs2302762, rs2302765, rs3853818, rs4151120, rs9217
Haplotype: rs4151120 - rs3853818 - rs2302765 - rs2302762 - rs9217(T-T-T-T-T)
rs2302762 showed nominally significant transmission bias; haploview analyses showed nominally significant transmission bias of rs4151120-rs3853818-rs2302765-rs2302762-rs9217; no evidence of interaction among these 19 cholinergic genes by FITF analysis and FDR correction was found Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 24)

GO terms by PBA (count: 4)

GO terms by database search (count: 20)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 15)

Literature-origin SNPs (count: 5)

LD-proxies (count: 10)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr17:7445061..7457707 View in gBrowse
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