Gene Report

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Basic Info

Approved Symbol	FGFRL1
Approved Name	fibroblast growth factor receptor-like 1
Location	4p16
Position	chr4:1009936-1026897, 1
External Links	HGNC: 3693 Entrez Gene: 53834 Ensembl: ENSG00000127418 UCSC: uc003gcg.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs4647931	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IDA[12813049]	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0060539	diaphragm development	biological process	IEA	2
GO:0030133	transport vesicle	cellular component	IDA[18061161]	4
GO:0044291	cell-cell contact zone	cellular component	IDA[18061161]	2
GO:0001501	skeletal system development	biological process	IEA	16
GO:0005007	fibroblast growth factor-activated receptor activity	molecular function	IDA[12813049]	2
GO:0060412	ventricular septum morphogenesis	biological process	IEA	3
GO:0051260	protein homooligomerization	biological process	IMP[18061161]	13
GO:0017134	fibroblast growth factor binding	molecular function	IEA	2
GO:0005794	Golgi apparatus	cellular component	IDA[18061161]	60
GO:0034446	substrate adhesion-dependent cell spreading	biological process	IDA[18061161]	5
GO:0008285	negative regulation of cell proliferation	biological process	IEA	41
GO:0003179	heart valve morphogenesis	biological process	IEA	1
GO:0051291	protein heterooligomerization	biological process	IGI[18061161]	8
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	IEA	21
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	biological process	IMP[18061161]	1
GO:0008201	heparin binding	molecular function	IDA[12813049]; IMP[18061161]	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FGFRL1	FGF2	NO	in vitro	11418238

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4647931	chr4:1025103 - 1025103(1)	downstream_gene_variant; missense_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
4p16.3	chr4:0-4500000	1 (1/0/0)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p16	chr4:0-11300000	2 (0/1/1)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:1009936..1026897 View in gBrowse