Gene Report

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Basic Info

Approved Symbol	CAPN10
Approved Name	calpain 10
Location	2q37.3
Position	chr2:240586716-240617705, 1
External Links	HGNC: 1477 Entrez Gene: 11132 Ensembl: ENSG00000142330 UCSC: uc002vzk.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00078, Product of P truncation <=0.01=0.00138, Product of P truncation <=0.001=0.00093. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008092	cytoskeletal protein binding	molecular function	ISS	6
GO:0005886	plasma membrane	cellular component	ISS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2000676	positive regulation of type B pancreatic cell apoptotic process	biological process	IEA	2
GO:0005623	cell	cellular component	IDA[17572128]	2
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	biological process	IC	3
GO:0031532	actin cytoskeleton reorganization	biological process	ISS[12974673]	8
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	molecular function	IMP[15044459]	1
GO:0000149	SNARE binding	molecular function	ISS	7
GO:0005829	cytosol	cellular component	IDA[16790502]; ISS	223
GO:0032869	cellular response to insulin stimulus	biological process	IMP[17572128]	12
GO:0006508	proteolysis	biological process	IMP[15044459]	34
GO:0005739	mitochondrion	cellular component	IDA[16790502]	75
GO:0032024	positive regulation of insulin secretion	biological process	IMP[15471947]	7
GO:0097050	type B pancreatic cell apoptotic process	biological process	IDA[15044459]	2
GO:0046326	positive regulation of glucose import	biological process	IMP[17572128]	7
GO:0032388	positive regulation of intracellular transport	biological process	ISS[12974673]	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1133353	chr2:240582850 - 240582850(1)	downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q37-2qter	chr2:230100000-242193529	1 (0/0/1)
2q37	chr2:230100000-242193529	1 (0/1/0)
2q37.3	chr2:236400000-242193529	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

View in gBrowse

Region: chr2:240586716..240617705 View in gBrowse