Gene Report

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Basic Info

Approved Symbol	LRRFIP1
Symbol Alias	FLAP-1, FLIIAP1, TRIP, GCF-2, HUFI-1
Approved Name	leucine rich repeat (in FLII) interacting protein 1
Name Alias	GC-binding factor 2
Location	2q37.3
Position	chr2:237627576-237813682, 1
External Links	HGNC: 6702 Entrez Gene: 9208 Ensembl: ENSG00000124831 UCSC: uc002vxe.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs11680933, rs1565853, rs2047169, rs3751112, rs3769086, rs3820813, rs4638738	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	TAS	49
GO:0005634	nucleus	cellular component	NAS[9705290]	283
GO:0003677	DNA binding	molecular function	IDA[23099021]	83
GO:0005886	plasma membrane	cellular component	IDA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[9705290]	21
GO:0032481	positive regulation of type I interferon production	biological process	TAS	2
GO:0005856	cytoskeleton	cellular component	TAS[9671805]	30
GO:0005575	cellular_component	cellular component	ND	19
GO:0003725	double-stranded RNA binding	molecular function	TAS[9671805]	9
GO:0005515	protein binding	molecular function	IPI[10366446]	563
GO:0005829	cytosol	cellular component	TAS	223
GO:0008150	biological_process	biological process	ND	24
GO:0045892	negative regulation of transcription, DNA-templated	biological process	NAS[9705290]	43
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0042803	protein homodimerization activity	molecular function	IDA[23099021]	71

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
LRRFIP1	FLII	NO	in vitro	9671805

Related other genetic factors

Gene related SNPs (count: 17)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3820813	chr2:237723264 - 237723264(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(0/1/0)
rs3751112	chr2:237586099 - 237586099(1)	coding_sequence_variant; downstream_gene_variant; intron_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs11680933	chr2:237696007 - 237696007(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs1565853	chr2:237721593 - 237721593(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)
rs2047169	chr2:237714770 - 237714770(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs4638738	chr2:237564221 - 237564221(1)	downstream_gene_variant; upstream_gene_variant	1(0/1/0)
rs3769086	chr2:237723104 - 237723104(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs3769090	chr2:237713147 - 237713147(1)	intron_variant; non_coding_transcript_variant
rs1038986	chr2:237721910 - 237721910(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs3769092	chr2:237709482 - 237709482(1)	intron_variant; non_coding_transcript_variant
rs3769095	chr2:237709110 - 237709110(1)	intron_variant; non_coding_transcript_variant
rs3754722	chr2:237703900 - 237703900(1)	intron_variant; non_coding_transcript_variant
rs3754726	chr2:237700987 - 237700987(1)	intron_variant; non_coding_transcript_variant
rs3769104	chr2:237700528 - 237700528(1)	intron_variant; non_coding_transcript_variant
rs3769106	chr2:237700028 - 237700028(1)	intron_variant; non_coding_transcript_variant
rs10171166	chr2:237694531 - 237694531(1)	intron_variant; non_coding_transcript_variant
rs1565854	chr2:237690288 - 237690288(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q37-2qter	chr2:230100000-242193529	1 (0/0/1)
2q37	chr2:230100000-242193529	1 (0/1/0)
2q37.3	chr2:236400000-242193529	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:237627576..237813682 View in gBrowse