Gene Report

Basic Info
Approved Symbol MED15
Previous Symbol TNRC7, PCQAP
Symbol Alias TIG-1, CAG7A, Arc105
Approved Name mediator complex subunit 15
Previous Name trinucleotide repeat containing 7, "PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein"
Location 22q11.2
Position chr22:20495913-20587632, 1
External Links HGNC: 14248
Entrez Gene: 51586
Ensembl: ENSG00000099917
UCSC: uc002zsq.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 6 SNP typed, Median D'=1, Median r<sup>2</sup> =0.2, 1 LD blocks, 0.68 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 11)

GO terms by PBA (count: 2)

GO terms by database search (count: 9)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 10)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

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Region: chr22:20495913..20587632 View in gBrowse
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