Gene Report

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Basic Info

Approved Symbol	MED15
Previous Symbol	TNRC7, PCQAP
Symbol Alias	TIG-1, CAG7A, Arc105
Approved Name	mediator complex subunit 15
Previous Name	trinucleotide repeat containing 7, "PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein"
Location	22q11.2
Position	chr22:20495913-20587632, 1
External Links	HGNC: 14248 Entrez Gene: 51586 Ensembl: ENSG00000099917 UCSC: uc002zsq.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		6 SNP typed, Median D'=1, Median r<sup>2</sup> =0.2, 1 LD blocks, 0.68 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0005634	nucleus	cellular component	IDA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0010467	gene expression	biological process	TAS	41
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	20
GO:0019827	stem cell maintenance	biological process	IEA	3
GO:0001104	RNA polymerase II transcription cofactor activity	molecular function	IEA	4
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IEA	21
GO:0016592	mediator complex	cellular component	IEA	5
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0005515	protein binding	molecular function	IPI[16799563]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 10)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MED15	ATP5C1	NO	yeast 2-hybrid	16169070
MED15	UBC	NO	in vivo	16904669
MED15	MLLT6	NO	yeast 2-hybrid	16189514
MED15	SMAD3	NO	in vivo	12167862
MED15	PLSCR1	NO	yeast 2-hybrid	16189514
MED15	ATXN1	YES	yeast 2-hybrid	16713569
MED15	TRIM11	NO	in vivo	16904669
MED15	FHL3	NO	yeast 2-hybrid	16189514
MED15	SMAD2	NO	in vivo	12167862
MED15	MED25	NO	in vivo	14983011

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_307	chr22:19046936-19795835 (Affymetrix SNP 6.0 array reference genome)	748899		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q11	chr22:15000000-25500000	1 (0/1/0)
22q11.2	chr22:17400000-25500000	2 (0/2/0)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Gene relationship with MDD

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Region: chr22:20495913..20587632 View in gBrowse