Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ADRA1B
Approved Name	adrenoceptor alpha 1B
Previous Name	adrenergic, alpha-1B-, receptor
Location	5q33.3
Position	chr5:159916783-159972544, 1
External Links	HGNC: 278 Entrez Gene: 147 Ensembl: ENSG00000170214 UCSC: uc003lxt.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	Other variant: ADRA1B_hcv1738292	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 31)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[22120526]	283
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[1328250]	158
GO:0007275	multicellular organismal development	biological process	TAS[10820200]	24

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007626	locomotory behavior	biological process	IEA	23
GO:0045819	positive regulation of glycogen catabolic process	biological process	IEA	1
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	biological process	IEA	2
GO:0035556	intracellular signal transduction	biological process	TAS[10820200]	38
GO:0043278	response to morphine	biological process	IEA	9
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[22120526]	13
GO:0071875	adrenergic receptor signaling pathway	biological process	IEA; TAS[1328250]	4
GO:0008283	cell proliferation	biological process	TAS[10820200]	37
GO:0042593	glucose homeostasis	biological process	IEA	19
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[2154750]	64
GO:0019229	regulation of vasoconstriction	biological process	IEA	10
GO:0001975	response to amphetamine	biological process	IEA	19
GO:0001974	blood vessel remodeling	biological process	IEA	8
GO:0031965	nuclear membrane	cellular component	IDA[22120526]	15
GO:0001987	vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure	biological process	IEA	1
GO:0055117	regulation of cardiac muscle contraction	biological process	IEA	6
GO:0007267	cell-cell signaling	biological process	TAS[1328250]	29
GO:0035265	organ growth	biological process	IEA	4
GO:0046982	protein heterodimerization activity	molecular function	IDA[22120526]	42
GO:0016049	cell growth	biological process	IEA	7
GO:0004937	alpha1-adrenergic receptor activity	molecular function	IEA	2
GO:0048148	behavioral response to cocaine	biological process	IEA	7
GO:0007512	adult heart development	biological process	IEA	3
GO:0045818	negative regulation of glycogen catabolic process	biological process	IEA	2
GO:0008542	visual learning	biological process	IEA	17
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[10820200]	10
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	biological process	IEA	2

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04020	Calcium signaling pathway	53

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
plcdPathway	Phospholipase C d1 in phospholipid associated cell signaling	2

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADRA1B	AP2M1	NO	in vitro;in vivo;yeast 2-hybrid	12644451
ADRA1B	STAT1	NO	in vivo	10652206
ADRA1B	FLNC	NO	yeast 2-hybrid	15525470
ADRA1B	GNA11	NO	in vivo	9481484
ADRA1B	SAG	NO	in vivo	8617782
ADRA1B	EZR	NO	in vitro;in vivo;yeast 2-hybrid	16352594
ADRA1B	PRKCA	NO	in vitro	9353340
ADRA1B	GNAQ	NO	in vivo	9481484
ADRA1B	PPP1R9B	NO	in vitro	17464283

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ADRA1B_hcv1738292	point mutation		1 (1/0/0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q31-q33	chr5:131200000-160500000	1 (1/0/0)
5q32-5q33.3	chr5:145100000-160500000	1 (0/1/0)
5q33	chr5:150400000-160500000	2 (0/1/1)
5q33-34	chr5:150400000-169000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:159916783..159972544 View in gBrowse