Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	NR4A2
Previous Symbol	NURR1
Symbol Alias	TINUR, NOT, RNR1, HZF-3
Approved Name	nuclear receptor subfamily 4, group A, member 2
Location	2q22-q23
Position	chr2:156324432-156342348, -1
External Links	HGNC: 7981 Entrez Gene: 4929 Ensembl: ENSG00000153234 UCSC: uc002tyz.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs278865	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 37)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003707	steroid hormone receptor activity	molecular function	IEA	10
GO:0005634	nucleus	cellular component	IDA[17184956]	283
GO:0030522	intracellular receptor signaling pathway	biological process	IEA; TAS[7877627]	8
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	molecular function	IEA	7

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001764	neuron migration	biological process	IEA	18
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0008344	adult locomotory behavior	biological process	IEA	15
GO:0017085	response to insecticide	biological process	IEA	1
GO:0043085	positive regulation of catalytic activity	biological process	IEA	4
GO:0010467	gene expression	biological process	TAS	41
GO:0042416	dopamine biosynthetic process	biological process	IEA	6
GO:0021952	central nervous system projection neuron axonogenesis	biological process	IEA	2
GO:0031668	cellular response to extracellular stimulus	biological process	IDA[7877627]	4
GO:0042053	regulation of dopamine metabolic process	biological process	IEA	6
GO:0043401	steroid hormone mediated signaling pathway	biological process	IEA	10
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IEA	5
GO:0009791	post-embryonic development	biological process	IEA	10
GO:0046982	protein heterodimerization activity	molecular function	IEA	42
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	91
GO:0043576	regulation of respiratory gaseous exchange	biological process	IEA	2
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0051866	general adaptation syndrome	biological process	IEA	1
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	20
GO:0006351	transcription, DNA-templated	biological process	IDA[17184956]	103
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0007165	signal transduction	biological process	NAS[7877627]	136
GO:0042551	neuron maturation	biological process	IEA	1
GO:0010035	response to inorganic substance	biological process	IEA	1
GO:0021986	habenula development	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[20195357]	563
GO:0001666	response to hypoxia	biological process	IEA	24
GO:0016265	death	biological process	IEA	3
GO:0043524	negative regulation of neuron apoptotic process	biological process	IEA	26
GO:0071542	dopaminergic neuron differentiation	biological process	ISS	2
GO:0034599	cellular response to oxidative stress	biological process	IEA	7
GO:0001975	response to amphetamine	biological process	IEA	19
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	molecular function	IEA	9

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa01510	Neurodegenerative Diseases	10

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NR4A2	CDKN1C	NO	in vitro	14671317
NR4A2	RXRB	NO	in vitro;in vivo;yeast 2-hybrid	7758108 , 7705655 , 15604093
NR4A2	RXRA	NO	in vitro;in vivo;yeast 2-hybrid	7758108 , 7705655 , 15604093
NR4A2	COPS5	NO	yeast 2-hybrid	15604093
NR4A2	RPS6KA1	NO	in vivo	16223362
NR4A2	VHL	NO	in vivo	18305400
NR4A2	PIAS4	YES	in vitro;in vivo;yeast 2-hybrid	14559918

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs278865	chr2:155563980 - 155563980(1)		1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q24	chr2:154000000-168900000	4 (0/3/1)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q24-33	chr2:154000000-208200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
20713499	Suggestive association was found with SZ.	Trend

Overlap with SZ from candidate gene intersection analysis (count: 7)

Reference	ID in SZGene	Result Category
11803525	282	Negative
11840500	282	Negative
12815740	282	Negative
20659174	282	Negative
18045777	282	Negative
11121187	282	Negative
12627459	282	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 2)

Reference	Description	Category in MDD	Link in MK4MDD
23064081		Pos	NR4A2
23087602	The greatest changes in expression were observed among transcriptional regulators, including downregulation in the expression of TOB1, EGR1, and NR4A2 and their downstream targets.	Pos	NR4A2

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Region: chr2:156324432..156342348 View in gBrowse