Gene Report

Basic Info
Approved Symbol GAD1
Previous Symbol GAD
Approved Name glutamate decarboxylase 1 (brain, 67kDa)
Previous Name glutamate decarboxylase 1 (brain, 67kD)
Location 2q31
Position chr2:170813213-170861151, 1
External Links HGNC: 4092
Entrez Gene: 2571
Ensembl: ENSG00000128683
UCSC: uc002ugi.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs769404, rs1978340, rs3749034, rs769390 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Lundorf, M. D.,2005 SNP: rs1978340, rs3749034, rs4668331, rs701492, rs769390, rs769395, rs872123
Haplotype: rs1978340 - rs872123(), rs1978340 - rs872123 - rs3749034(), rs4668331 - rs769395(), rs872123 - rs3749034(), rs872123 - rs3749034 - rs769404()
Other variant: rs769404
The results from the association studies indicate that promoter variants are of importance for the Danish BPADcases and we cannot reject the hypothesis of GAD1 as a functional candidate gene for BPAD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 18)

GO terms by PBA (count: 2)

GO terms by database search (count: 16)

Gene related KEGG pathways (count: 6)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 6)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 24)

Literature-origin SNPs (count: 9)

LD-proxies (count: 15)

Gene related CNVs (count: 1)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 8)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 3)

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Region: chr2:170813213..170861151 View in gBrowse
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