Gene Report

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Basic Info

Approved Symbol	PALLD
Symbol Alias	KIAA0992, SIH002, CGI-151
Approved Name	palladin, cytoskeletal associated protein
Location	4q32.3
Position	chr4:168497066-168928457, 1
External Links	HGNC: 17068 Entrez Gene: 23022 Ensembl: ENSG00000129116 UCSC: uc011cjx.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0036. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA	360
GO:0003779	actin binding	molecular function	IEA	24
GO:0005634	nucleus	cellular component	IDA[11598191]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005739	mitochondrion	cellular component	IDA	75
GO:0030027	lamellipodium	cellular component	IEA	9
GO:0005884	actin filament	cellular component	IDA[11598191]	9
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0001726	ruffle	cellular component	IEA	10
GO:0030018	Z disc	cellular component	IEA	16
GO:0007010	cytoskeleton organization	biological process	NAS[11598191]	11
GO:0051371	muscle alpha-actinin binding	molecular function	TAS[16125169]	1
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005515	protein binding	molecular function	IPI[11598191]	563
GO:0015629	actin cytoskeleton	cellular component	IDA	18

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PALLD	ITGB5	NO	yeast 2-hybrid	16355270
PALLD	ACTN1	NO	in vitro;in vivo;yeast 2-hybrid	15147863
PALLD	EZR	NO	in vitro;in vivo	1159819 , 11598191
PALLD	ACTN2	NO	in vivo	10931874

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4q31.22-34.1	chr4:145900000-175400000	1 (0/0/1)
4q32	chr4:154600000-169200000	3 (0/0/3)
4q31-35	chr4:138500000-190214555	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:168497066..168928457 View in gBrowse