Gene Report

Basic Info
Approved Symbol AVPR1B
Previous Symbol AVPR3
Approved Name arginine vasopressin receptor 1B
Location 1q32
Position chr1:206109692-206117699, -1
External Links HGNC: 896
Entrez Gene: 553
Ensembl: ENSG00000198049
UCSC: uc001hds.2
No. of Studies 4 (Positive: 3; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Szczepankiewicz, A., 2013 Haplotype: rs28536160 - rs28373064 - rs35369693 (A-G-G ), rs28536160 - rs28373064 - rs35369693 (G-G-G ), rs28536160 - rs28373064 - rs35369693 (G-C-A ), rs28536160 - rs28373064 - rs35369693 (G-G-A ) Polymorphisms of CRHR1 and AVPR1b may modify susceptibility to mood disorders. Positive Comment on Study
Leszczynska-Rodziewicz, A., 2012 SNP: rs28373064, rs28536160, rs28632197, rs35369693 Our results suggest possible role of the polymorphisms in the AVPR1b and CRHR1 genes and the etiology of psychotic features in depression in the course of bipolar type I disorder. Positive Comment on Study
Leszczynska-Rodziewicz A, 2013 In our study we found no association between melancholic depression and polymorphisms in this gene. Negative Comment on Study
Koefoed, P.,2011 SNP: rs33976516 AVPR1B_rs33976516=1 (one indicate heterozygocity)occurred in 46 3-combinations.In 1000 permutation tests, at least one cluster of this type (with at least 37 pseudo-patients) were seen 42 times (p=0.042), two such clusters were seen 3 times (p=0.003), and at least three or more clusters of this type did not occur once(p<0.001).. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 2)

GO terms by database search (count: 11)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 6)

Literature-origin SNPs (count: 5)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr1:206109692..206117699 View in gBrowse
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