Gene Report

Basic Info
Approved Symbol FYN
Symbol Alias SYN, SLK, MGC45350
Approved Name FYN proto-oncogene, Src family tyrosine kinase
Previous Name FYN oncogene related to SRC, FGR, YES
Location 6q21
Position chr6:111660332-111873452, -1
External Links HGNC: 4037
Entrez Gene: 2534
Ensembl: ENSG00000010810
UCSC: uc003pvh.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Szczepankiewicz, A.,2009(a) SNP: rs3730353, rs6916861, rs706895
Haplotype: rs6916861 - rs3730353(G-C), rs6916861 - rs3730353(T-T)
The results suggest that the glutamatergic FYN gene may be associated with bipolar disorder, particularly with type I illness and early age of onset. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 73)

GO terms by PBA (count: 7)

GO terms by database search (count: 66)

Gene related KEGG pathways (count: 8)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 7)

Gene related BioCarta pathways (count: 9)

Gene related interactors from protein-protein interactions data in HPRD (count: 151)

Related other genetic factors
Gene related SNPs (count: 14)

Literature-origin SNPs (count: 3)

LD-proxies (count: 11)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr6:111660332..111873452 View in gBrowse
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