Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	FYN
Symbol Alias	SYN, SLK, MGC45350
Approved Name	FYN proto-oncogene, Src family tyrosine kinase
Previous Name	FYN oncogene related to SRC, FGR, YES
Location	6q21
Position	chr6:111660332-111873452, -1
External Links	HGNC: 4037 Entrez Gene: 2534 Ensembl: ENSG00000010810 UCSC: uc003pvh.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Szczepankiewicz, A.,2009(a)	SNP: rs3730353, rs6916861, rs706895 Haplotype: rs6916861 - rs3730353(G-C), rs6916861 - rs3730353(T-T)	The results suggest that the glutamatergic FYN gene may be associated with bipolar disorder, particularly with type I illness and early age of onset.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 73)

GO terms by PBA (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	IBA; TAS	49
GO:0005634	nucleus	cellular component	IEA	283
GO:0007411	axon guidance	biological process	TAS	60
GO:0005886	plasma membrane	cellular component	IDA[12150984]	360
GO:0006816	calcium ion transport	biological process	NAS[7822789]	14
GO:0030154	cell differentiation	biological process	IBA	31
GO:0007417	central nervous system development	biological process	IBA	21

GO terms by database search (count: 66)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0050852	T cell receptor signaling pathway	biological process	IDA[7722293]	9
GO:0006468	protein phosphorylation	biological process	NAS[7822789]	42
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0046875	ephrin receptor binding	molecular function	IPI[10498895]	5
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	TAS	9
GO:0045471	response to ethanol	biological process	IEA	24
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IEA	14
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	cellular component	IBA	6
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	biological process	IEA	9
GO:0042608	T cell receptor binding	molecular function	IEA	2
GO:0008360	regulation of cell shape	biological process	IEA	16
GO:0007631	feeding behavior	biological process	TAS[8264796]	12
GO:0001664	G-protein coupled receptor binding	molecular function	IEA	9
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	22
GO:0048015	phosphatidylinositol-mediated signaling	biological process	TAS	17
GO:0004715	non-membrane spanning protein tyrosine kinase activity	molecular function	NAS[7822789]	4
GO:0030168	platelet activation	biological process	TAS	22
GO:0048013	ephrin receptor signaling pathway	biological process	TAS	11
GO:0007596	blood coagulation	biological process	TAS	44
GO:0010976	positive regulation of neuron projection development	biological process	IEA	10
GO:0051428	peptide hormone receptor binding	molecular function	IEA	2
GO:0004713	protein tyrosine kinase activity	molecular function	EXP; TAS	9
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	12
GO:0042610	CD8 receptor binding	molecular function	IEA	1
GO:0031295	T cell costimulation	biological process	TAS	6
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	21
GO:0015631	tubulin binding	molecular function	IEA	5
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	biological process	IEA	8
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	19
GO:0042493	response to drug	biological process	IEA	57
GO:0005884	actin filament	cellular component	IEA	9
GO:0042177	negative regulation of protein catabolic process	biological process	IEA	5
GO:0044325	ion channel binding	molecular function	IEA	14
GO:0036120	cellular response to platelet-derived growth factor stimulus	biological process	IEA	2
GO:0043548	phosphatidylinositol 3-kinase binding	molecular function	IEA	4
GO:0045121	membrane raft	cellular component	IDA[12150984]	22
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	biological process	IEA	4
GO:0016477	cell migration	biological process	IBA	17
GO:0016032	viral process	biological process	TAS	26
GO:0070851	growth factor receptor binding	molecular function	IPI[16479011]	1
GO:0071375	cellular response to peptide hormone stimulus	biological process	IBA	2
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0007612	learning	biological process	TAS[1361685]	18
GO:0048813	dendrite morphogenesis	biological process	IEA	5
GO:0042110	T cell activation	biological process	IBA	9
GO:0001948	glycoprotein binding	molecular function	IPI[16831868]	4
GO:0042127	regulation of cell proliferation	biological process	IBA	14
GO:0050798	activated T cell proliferation	biological process	IEA	1
GO:0050900	leukocyte migration	biological process	TAS	9
GO:1900182	positive regulation of protein localization to nucleus	biological process	IEA	3
GO:0030900	forebrain development	biological process	IEA	5
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0038083	peptidyl-tyrosine autophosphorylation	biological process	IBA	4
GO:0005515	protein binding	molecular function	IPI[10209036]	563
GO:0050690	regulation of defense response to virus by virus	biological process	TAS	4
GO:0035556	intracellular signal transduction	biological process	TAS[1361685]	38
GO:0010629	negative regulation of gene expression	biological process	IEA	12
GO:0005829	cytosol	cellular component	TAS	223
GO:0043524	negative regulation of neuron apoptotic process	biological process	IEA	26
GO:0005524	ATP binding	molecular function	IEA	118
GO:0001764	neuron migration	biological process	IEA	18
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	IBA	16
GO:0005768	endosome	cellular component	IDA[15611048]	27
GO:0042981	regulation of apoptotic process	biological process	IBA	10
GO:0042609	CD4 receptor binding	molecular function	IEA	1

Gene related KEGG pathways (count: 8)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04510	Focal adhesion	22

KEGG pathways by database search (count: 7)

ID	Name	No. of Genes in BDgene
hsa05131	EPEC	6
hsa05130	Pathogenic Escherichia coli infection	6
hsa04520	Adherens junction	11
hsa04664	Fc epsilon RI signaling pathway	13
hsa04360	Axon guidance	16
hsa04650	Natural killer cell mediated cytotoxicity	13
hsa04660	T cell receptor signaling pathway	13

Gene related BioCarta pathways (count: 9)

BioCarta pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
reelinPathway	Reelin Signaling Pathway	4

BioCarta pathways by database search (count: 8)

ID	Name	No. of Genes in BDgene
tcrPathway	T Cell Receptor Signaling Pathway	7
tcraPathway	Lck and Fyn tyrosine kinases in initiation of TCR Activation	1
ecmPathway	Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia	4
tsp1Pathway	TSP-1 Induced Apoptosis in Microvascular Endothelial Cell	2
integrinPathway	Integrin Signaling Pathway	3
ephA4Pathway	Eph Kinases and ephrins support platelet aggregation	1
il7Pathway	IL-7 Signal Transduction	6
biopeptidesPathway	Bioactive Peptide Induced Signaling Pathway	4

Gene related interactors from protein-protein interactions data in HPRD (count: 151)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FYN	PDGFRB	YES	in vivo	1696179 , 9425276
FYN	PRKCE	YES	in vitro	8621384
FYN	SH2B2	NO	in vivo	10872802
FYN	SNCA	NO	in vitro;in vivo	11162638 , 12096713 , 11744621
FYN	HNRNPK	NO	in vitro;yeast 2-hybrid	7516469 , 9185665
FYN	TXK	NO	in vitro;in vivo	11353545
FYN	CD226	NO	in vivo	10591186
FYN	IL2RB	YES	in vivo	8483935
FYN	SNX26	NO	in vivo;yeast 2-hybrid	16777849
FYN	CD2	NO	in vitro;in vivo	9677430
FYN	TUBA4A	NO	in vitro;in vivo	8566014
FYN	CD36	YES	in vivo	7521304
FYN	GAB3	NO	in vitro	11739737
FYN	PLAUR	NO	in vitro;in vivo	9417082
FYN	RAF1	NO	in vitro;in vivo	7517401
FYN	MCAM	NO	in vivo	9756930
FYN	ACP1	NO	in vitro;in vivo	9038134
FYN	TRPC6	NO	in vitro;in vivo	14761972
FYN	FCER2	NO	in vivo	1387715 , 1446976 , 1717997
FYN	PTK2	NO	in vitro	11278857
FYN	KDR	NO	in vitro	7929439
FYN	WASF2	NO	in vivo	10532312
FYN	PLD2	NO	in vivo	12697812
FYN	TUBA3C	NO	in vitro;in vivo	11826099 , 8566014
FYN	CSK	NO	in vitro;in vivo	8262983 , 1985196
FYN	JAK2	NO	in vivo	10551884
FYN	PIK3R1	YES	in vitro;in vivo	8394019 , 8294442
FYN	CAV1	NO	in vivo	12529448
FYN	NMT1	NO	in vitro;in vivo	11423543 , 11594778
FYN	SIT1	NO	in vivo	10209036
FYN	NPHS1	NO	in vivo	12846735 , 12668668
FYN	SPHK1	NO	in vivo	16316995
FYN	CD5	NO	in vitro;in vivo	11298344 , 15144186
FYN	BCAR1	NO	in vitro;in vivo	9188452
FYN	STAT1	NO	in vivo	9804857
FYN	SPN	NO	in vitro;in vivo	9603925
FYN	ADAM15	NO	in vivo	11741929 , 16374509
FYN	CDK5	NO	in vivo	12372285
FYN	FASLG	NO	in vitro	7589480
FYN	BCL3	NO	in vivo	9576921
FYN	LCP2	NO	in vivo	9047237
FYN	ITPR1	NO	in vitro	14761954
FYN	TYK2	NO	in vitro;in vivo	9196040
FYN	CRK	NO	in vivo	9837978
FYN	SH3BP2	NO	in vitro	15345594
FYN	FCGR2A	NO	in vitro;in vivo	8756631
FYN	PXN	NO	in vivo	10804218
FYN	ITK	YES	in vitro;in vivo	8810341
FYN	DOK3	NO	in vitro	10733577
FYN	NEDD9	NO	in vitro;in vivo	9360983
FYN	PLCG1	YES	in vitro;in vivo	10586033
FYN	PTPRF	NO	in vivo	12496362
FYN	CD48	NO	in vitro	8104794
FYN	CD247	NO	in vitro;in vivo	1454062 , 1530920 , 7589084 , 8760790 , 9368621
FYN	SYK	NO	in vitro;in vivo	9535867
FYN	CD19	NO	in vitro;in vivo	7589101
FYN	PIK3R2	NO	in vivo	1334406
FYN	KHDRBS1	NO	in vitro;in vivo	9045636 , 7516469
FYN	MAG	NO	in vitro;in vivo	7525550
FYN	TNK2	YES	in vitro;in vivo	14506255 , 11087735
FYN	SKAP2	NO	in vivo	9837776
FYN	IRS1	NO	in vitro;in vivo	8631859
FYN	CASP8	NO	in vitro	10435619
FYN	MS4A1	NO	in vitro	7545683
FYN	IL7R	NO	in vitro;in vivo	7515933
FYN	FLOT2	NO	in vivo	11598189
FYN	PRKCZ	YES	in vitro	8621384
FYN	PTPRZ1	YES	in vitro;yeast 2-hybrid	15925565
FYN	CD79A	NO	in vitro;in vivo	9531288
FYN	EVL	NO	in vitro	10945997
FYN	CD55	NO	in vivo	1385527
FYN	GRAP	NO	in vitro;in vivo	8995379
FYN	CDK1	NO	in vivo	8910336
FYN	WASF1	NO	in vivo	10532312
FYN	PRKCH	NO	in vitro	8621384
FYN	PTPN5	NO	in vitro;in vivo	11983687
FYN	KIT	NO	in vitro;in vivo	12374739 , 9799234
FYN	PTK2B	YES	in vitro;in vivo	9091579 , 10867021 , 9104812
FYN	CTLA4	YES	in vitro;in vivo	9712716 , 9973379
FYN	SOS1	NO	in vitro	9856337
FYN	CNTNAP1	NO	in vitro	9118959
FYN	PTPRC	YES	in vitro;in vivo	9368621 , 12589038 , 9535845 , 8980254
FYN	DOK1	NO	in vitro	15345598
FYN	THY1	NO	in vivo	1351058
FYN	DLG4	NO	in vivo	12419528
FYN	MAP2	NO	in vitro;in vivo	15536091
FYN	CTNNB1	NO	in vitro	12640114
FYN	SDC3	NO	in vitro	9553134
FYN	GRIN2A	YES	in vitro;in vivo	12932824 , 10458595
FYN	CNN1	NO	in vitro;in vivo	15206927
FYN	TUBA1B	YES	in vitro;in vivo	11826099
FYN	GNB2L1	NO	in vitro;in vivo	11943848 , 12524444
FYN	PLCG2	YES	in vitro;in vivo	8395016 , 12181444 , 7682059 , 15144186
FYN	CNN3	NO	in vitro;in vivo	15206927
FYN	SKAP1	NO	in vitro;in vivo	9195899
FYN	EPHB3	NO	in vitro;in vivo;yeast 2-hybrid	9674711
FYN	SPHK2	YES	in vivo	16316995
FYN	FLOT1	YES	in vivo	11598189
FYN	SLAMF1	NO	in vitro;in vivo	12458214 , 11806999
FYN	MED28	NO	in vitro;in vivo;yeast 2-hybrid	16899217
FYN	CTNND2	YES	in vitro;in vivo	12835311
FYN	CNTN1	NO	in vivo	7595520
FYN	PTPRA	NO	in vivo	9535845 , 8980254
FYN	NR3C1	YES	in vivo	16888650
FYN	PTPN11	NO	in vitro	10212213
FYN	GRB2	NO	yeast 2-hybrid	9344857
FYN	CD44	NO	in vitro;in vivo	9573028
FYN	CD2AP	NO	in vitro;in vivo	10339567
FYN	FYB	NO	in vitro;in vivo	7504057 , 9207119 , 10570256
FYN	DOK4	NO	in vitro;in vivo	12730241
FYN	JUP	NO	in vitro	14517306
FYN	PAG1	NO	in vitro;in vivo	10790433
FYN	HRAS	NO	in vitro	12695509
FYN	PAK2	NO	in vitro	16374509
FYN	MAPT	YES	in vitro;in vivo	11826099 , 16014719
FYN	FAS	NO	in vivo	8626376
FYN	PECAM1	NO	in vitro;in vivo	10858437
FYN	EPHA4	NO	in vivo	12084815
FYN	YTHDC1	NO	in vitro	15175272
FYN	WAS	NO	in vivo	10224664 , 8805332 , 10532312 , 7565724
FYN	ATXN1	YES	yeast 2-hybrid	16713569
FYN	CD79B	NO	in vitro;in vivo	9531288
FYN	GRB10	NO	in vitro;in vivo	10871840
FYN	CBLB	NO	in vitro	16503409
FYN	VAV1	NO	in vitro;in vivo	9822663
FYN	CASP3	NO	in vitro;in vivo	10435619
FYN	GP6	NO	in vitro	11943772 , 1715582
FYN	TOM1L1	NO	in vitro;yeast 2-hybrid	11711534
FYN	SOCS1	NO	in vitro	10022833
FYN	SHC1	NO	in vitro;in vivo	7516469 , 12237775 , 11075717 , 10764799 , 9121430 , 9446569 , 10816433 , 10896916 , 10921922 , 9741627 , 9710204 , 10482988
FYN	HSP90AA1	YES	in vivo	16888650
FYN	CSF1R	NO	in vivo	7681396
FYN	CSF2RB	YES	in vitro;in vivo	9195918
FYN	FLT1	NO	in vivo	12509223
FYN	TRAT1	NO	in vitro	9687533
FYN	HTR6	YES	in vitro;in vivo;yeast 2-hybrid	17189269
FYN	ITGB4	NO	in vitro;in vivo	11684709
FYN	PRKCQ	NO	in vitro;yeast 2-hybrid	10383400
FYN	CBL	NO	in vitro;in vivo;yeast 2-hybrid	9535867 , 8621719 , 11994282 , 11239464 , 9890970 , 10092522 , 10799548 , 7642581
FYN	ADD2	NO	in vivo	11526103
FYN	ZAP70	NO	in vivo	7760813
FYN	SH2D1A	NO	in vitro;in vivo	12545174 , 10089404
FYN	TYRO3	NO	in vivo	7537495
FYN	PTPRE	YES	in vitro	14980517 , 15588985
FYN	FNBP4	NO	in vitro	10744724
FYN	GRIN2B	YES	in vitro;in vivo	10458595 , 11024032 , 11483655
FYN	EPHA8	NO	in vitro;in vivo	10498895
FYN	NTRK2	YES	in vitro;in vivo	9648856
FYN	UNC119	NO	in vitro;in vivo	14757743
FYN	PRKCD	NO	in vitro	8621384
FYN	TRPV4	NO	in vitro;in vivo	12538589

Related other genetic factors

Gene related SNPs (count: 14)

Literature-origin SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs706895	chr6:111720156 - 111720156(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)
rs6916861	chr6:111661054 - 111661054(1)	3_prime_UTR_variant; downstream_gene_variant	1(1/0/0)
rs3730353	chr6:111674463 - 111674463(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 11)

rs_ID	Location	Functional Annotation
rs809193	chr6:111699211 - 111699211(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs1740377	chr6:111721915 - 111721915(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs1726113	chr6:111721930 - 111721930(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs11153311	chr6:111688122 - 111688122(1)	intron_variant; non_coding_transcript_variant
rs2237257	chr6:111683923 - 111683923(1)	intron_variant; non_coding_transcript_variant
rs2237250	chr6:111663878 - 111663878(1)	intron_variant; non_coding_transcript_variant
rs12191154	chr6:111663112 - 111663112(1)	intron_variant; non_coding_transcript_variant
rs4947139	chr6:111657541 - 111657541(1)	downstream_gene_variant
rs1621289	chr6:111662976 - 111662976(1)	intron_variant; non_coding_transcript_variant
rs1726131	chr6:111656657 - 111656657(1)	downstream_gene_variant
rs9372309	chr6:111726395 - 111726395(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6q16-q21	chr6:100000000-114200000	1 (0/0/1)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q21	chr6:105000000-114200000	4 (1/2/1)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q21-22	chr6:105000000-130000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
11121167	368	Negative

Gene relationship with MDD

View in gBrowse

Region: chr6:111660332..111873452 View in gBrowse