Gene Report

Basic Info
Approved Symbol NEFL
Symbol Alias NFL, CMT1F, CMT2E, NF68, PPP1R110
Approved Name neurofilament, light polypeptide
Previous Name neurofilament, light polypeptide 68kDa
Name Alias protein phosphatase 1, regulatory subunit 110
Location 8p21.2
Position chr8:24950955-24957110, -1
External Links HGNC: 7739
Entrez Gene: 4747
Ensembl: ENSG00000277586
UCSC: uc033bfe.1
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.1, 1 LD blocks, 7.17 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 31)

GO terms by PBA (count: 3)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr8:24950955..24957110 View in gBrowse
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