Gene Report

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Basic Info

Approved Symbol	SIGLEC6
Previous Symbol	CD33L, CD33L1
Symbol Alias	OB-BP1, SIGLEC-6, CD327
Approved Name	sialic acid binding Ig-like lectin 6
Location	19q13.3
Position	chr19:51519525-51531856, -1
External Links	HGNC: 10875 Entrez Gene: 946 Ensembl: ENSG00000105492 UCSC: uc002pwy.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00069, Product of P truncation <=0.01=0.00211, Product of P truncation <=0.001=0.00087. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	TAS[9465907]	137
GO:0007155	cell adhesion	biological process	IEA	42
GO:0005887	integral component of plasma membrane	cellular component	TAS[9465907]	158
GO:0030246	carbohydrate binding	molecular function	IEA	6

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005576	extracellular region	cellular component	IEA	97
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0007267	cell-cell signaling	biological process	TAS[9465907]	29

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SIGLEC6	LEP	NO	in vitro	10428856

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
19p13-q13	chr19:0-58617616	1 (0/1/0)
Chr 19	chr19:0-58617616	2 (0/2/0)
19q13	chr19:31900000-58617616	2 (0/2/0)
19q13.33-qter	chr19:47500000-58617616	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr19:51519525..51531856 View in gBrowse