Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	TRIM24
Previous Symbol	TIF1
Symbol Alias	hTIF1, Tif1a, RNF82, TIF1A
Approved Name	tripartite motif containing 24
Previous Name	transcriptional intermediary factor 1, "tripartite motif-containing 24"
Location	7q32-q34
Position	chr7:138460334-138589993, 1
External Links	HGNC: 11812 Entrez Gene: 8805 Ensembl: ENSG00000122779 UCSC: uc003vuc.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		TRIM24 has been implicated in SCZ.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 33)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283
GO:0004672	protein kinase activity	molecular function	IEA	13
GO:0043565	sequence-specific DNA binding	molecular function	IEA	29
GO:0005102	receptor binding	molecular function	TAS[9115274]	37

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:1901796	regulation of signal transduction by p53 class mediator	biological process	IEA	1
GO:0055074	calcium ion homeostasis	biological process	IEA	4
GO:0008285	negative regulation of cell proliferation	biological process	IEA	41
GO:0043434	response to peptide hormone	biological process	IEA	9
GO:0042981	regulation of apoptotic process	biological process	IMP[19556538]	10
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS[9115274]	31
GO:0016874	ligase activity	molecular function	IEA	16
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IEA	58
GO:0031647	regulation of protein stability	biological process	IMP[19556538]	5
GO:0002039	p53 binding	molecular function	IPI[19556538]	7
GO:0070562	regulation of vitamin D receptor signaling pathway	biological process	IEA	1
GO:0004842	ubiquitin-protein transferase activity	molecular function	IDA[19556538]	12
GO:0035064	methylated histone binding	molecular function	IDA[21164480]	3
GO:0005515	protein binding	molecular function	IPI[19909775]	563
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0046777	protein autophosphorylation	biological process	IEA	16
GO:0034056	estrogen response element binding	molecular function	IDA[21164480]	2
GO:0005719	nuclear euchromatin	cellular component	IEA	5
GO:0016922	ligand-dependent nuclear receptor binding	molecular function	IEA	1
GO:0005726	perichromatin fibrils	cellular component	IEA	1
GO:0030163	protein catabolic process	biological process	IMP[19556538]	5
GO:0003682	chromatin binding	molecular function	IDA[21164480]	23
GO:0016567	protein ubiquitination	biological process	IDA[19556538]; IEA	18
GO:0071391	cellular response to estrogen stimulus	biological process	IDA[21164480]	2
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IEA	43
GO:0005829	cytosol	cellular component	TAS	223
GO:0070577	lysine-acetylated histone binding	molecular function	IDA[21164480]	1
GO:0003713	transcription coactivator activity	molecular function	IDA[21164480]	22
GO:0008270	zinc ion binding	molecular function	IDA[21164480]	77

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 25)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRIM24	TRIM33	NO	in vitro;in vivo	12096914
TRIM24	AR	NO	in vitro	9115274
TRIM24	ZNF10	NO	yeast 2-hybrid	9016654
TRIM24	TAF1B	NO	in vitro	12393749
TRIM24	VDR	NO	in vivo	9115274
TRIM24	TAF1C	NO	in vitro	12393749
TRIM24	TAF7	NO	in vitro	9632676
TRIM24	HSPA1A	YES	in vitro;in vivo	12677068
TRIM24	PML	NO	in vivo	10610177
TRIM24	ESR2	NO	in vitro	10598587
TRIM24	CBX5	NO	in vitro	10562550
TRIM24	TRIM28	NO	in vitro;in vivo	12684500
TRIM24	NR2F2	NO	in vitro	9115274
TRIM24	NR3C1	YES	in vivo	9115274
TRIM24	RXRA	NO	in vitro;in vivo	11851396 , 9115274 , 9632676
TRIM24	NR3C2	YES	in vitro	9115274 , 11518808
TRIM24	RARA	NO	in vivo	9115274
TRIM24	PGR	NO	in vivo	9115274
TRIM24	TAF11	NO	in vitro	9632676
TRIM24	THRA	YES	in vivo	9115274
TRIM24	GTF2E1	NO	in vitro	9632676
TRIM24	HNF4A	YES	in vitro	9115274
TRIM24	CBX1	NO	in vitro	10562550
TRIM24	CBX3	NO	in vitro	10562550
TRIM24	SUMO1	NO	in vitro;in vivo	11313457

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr7:138460334..138589993 View in gBrowse