Gene Report

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Basic Info

Approved Symbol	ITGB6
Approved Name	integrin, beta 6
Location	2q24.2
Position	chr2:160099666-160271888, -1
External Links	HGNC: 6161 Entrez Gene: 3694 Ensembl: ENSG00000115221 UCSC: uc010fov.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs10497212	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043235	receptor complex	cellular component	IDA[23382219]	20
GO:0007275	multicellular organismal development	biological process	IEA	24
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0006954	inflammatory response	biological process	IEA	23
GO:0007155	cell adhesion	biological process	TAS[2365683]	42

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007160	cell-matrix adhesion	biological process	IEA	11
GO:0007229	integrin-mediated signaling pathway	biological process	IEA	4
GO:0008305	integrin complex	cellular component	IEA	3
GO:0005178	integrin binding	molecular function	IEA	8
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0001618	virus receptor activity	molecular function	IEA	3
GO:0009897	external side of plasma membrane	cellular component	IEA	21
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0046718	viral entry into host cell	biological process	IEA	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04510	Focal adhesion	22
hsa04512	ECM-receptor interaction	9

ID	Name	No. of Genes in BDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ITGB6	FHL2	NO	in vitro;yeast 2-hybrid	10906324
ITGB6	TGFB1	NO	in vivo	10025398
ITGB6	ITGAV	NO	in vivo	1532572 , 8120056
ITGB6	FN1	NO	in vitro	1532572
ITGB6	VTN	NO	in vitro	8120056

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10497212	chr2:160108189 - 160108189(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs16844790	chr2:160112117 - 160112117(1)	3_prime_UTR_variant; NMD_transcript_variant; synonymous_variant; upstream_gene_variant
rs16844802	chr2:160114224 - 160114224(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs17284082	chr2:160140215 - 160140215(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs7581712	chr2:160144658 - 160144658(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3111395	chr2:160170683 - 160170683(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7603686	chr2:160171327 - 160171327(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3111397	chr2:160194852 - 160194852(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4665154	chr2:160099385 - 160099385(1)	downstream_gene_variant
rs4076843	chr2:160100994 - 160100994(1)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant
rs4078236	chr2:160101948 - 160101948(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4665156	chr2:160110758 - 160110758(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q24	chr2:154000000-168900000	4 (0/3/1)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q24-33	chr2:154000000-208200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:160099666..160271888 View in gBrowse