Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PICK1
Previous Symbol	PRKCABP
Symbol Alias	dJ1039K5, MGC15204
Approved Name	protein interacting with PRKCA 1
Previous Name	protein kinase C, alpha binding protein, "protein interacting with PRKCA"
Location	22q13.1
Position	chr22:38056311-38075701, 1
External Links	HGNC: 9394 Entrez Gene: 9463 Ensembl: ENSG00000100151 UCSC: uc003aus.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		5 SNP typed, Median D'=1, Median r<sup>2</sup> =0.28, 1 LD blocks, 0.84 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA. This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 45)

GO terms by PBA (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045211	postsynaptic membrane	cellular component	IEA	68
GO:0005886	plasma membrane	cellular component	IDA[11343649]; TAS	360
GO:0051015	actin filament binding	molecular function	ISS	9
GO:0019904	protein domain specific binding	molecular function	ISS	24
GO:0005102	receptor binding	molecular function	ISS	37
GO:0045202	synapse	cellular component	ISS	29
GO:0007268	synaptic transmission	biological process	TAS	116

GO terms by database search (count: 38)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005080	protein kinase C binding	molecular function	IBA; ISS	7
GO:0005737	cytoplasm	cellular component	IDA[11343649]	322
GO:0060292	long term synaptic depression	biological process	ISS	5
GO:0045161	neuronal ion channel clustering	biological process	TAS[11343649]	1
GO:0021782	glial cell development	biological process	ISS	1
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	biological process	NAS[10623590]	2
GO:0030666	endocytic vesicle membrane	cellular component	TAS	8
GO:0097062	dendritic spine maintenance	biological process	ISS	2
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS	50
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	ISS	1
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0097061	dendritic spine organization	biological process	ISS	1
GO:0001664	G-protein coupled receptor binding	molecular function	ISS	9
GO:0071933	Arp2/3 complex binding	molecular function	ISS	1
GO:0008022	protein C-terminus binding	molecular function	IPI[11343649]	21
GO:0043005	neuron projection	cellular component	ISS	38
GO:0016887	ATPase activity	molecular function	ISS	13
GO:0043045	DNA methylation involved in embryo development	biological process	NAS[12138111]	1
GO:0006468	protein phosphorylation	biological process	ISS	42
GO:0005515	protein binding	molecular function	IPI[11802773]	563
GO:0048167	regulation of synaptic plasticity	biological process	IBA	9
GO:0002092	positive regulation of receptor internalization	biological process	IBA; ISS	4
GO:0043113	receptor clustering	biological process	IBA; ISS	8
GO:0043046	DNA methylation involved in gamete generation	biological process	TAS[12138111]	2
GO:0042734	presynaptic membrane	cellular component	IDA[11343649]	16
GO:0015844	monoamine transport	biological process	IDA[11343649]	6
GO:0036294	cellular response to decreased oxygen levels	biological process	ISS	1
GO:0030054	cell junction	cellular component	IEA	88
GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	biological process	IBA	1
GO:0019899	enzyme binding	molecular function	IPI[16314870]	34
GO:0042149	cellular response to glucose starvation	biological process	ISS	7
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0097481	neuronal postsynaptic density	cellular component	IEA	6
GO:0006605	protein targeting	biological process	IEA	5
GO:0005794	Golgi apparatus	cellular component	ISS	60
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	biological process	IDA[10623590]	7
GO:0042802	identical protein binding	molecular function	ISS	44
GO:0005856	cytoskeleton	cellular component	IEA	30

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 33)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PICK1	CIC	NO	yeast 2-hybrid	16713569
PICK1	EPHB2	NO	in vitro;yeast 2-hybrid	9883737 , 10839360
PICK1	UBQLN4	NO	yeast 2-hybrid	16713569
PICK1	GFI1	NO	yeast 2-hybrid	16713569
PICK1	ERBB2	YES	in vitro;in vivo;yeast 2-hybrid	11278603
PICK1	LRP2BP	YES	yeast 2-hybrid	12508107
PICK1	EFNB1	NO	in vivo;yeast 2-hybrid	9883737
PICK1	ATXN7L3	NO	yeast 2-hybrid	16713569
PICK1	ATXN7	NO	yeast 2-hybrid	16713569
PICK1	GRIA4	NO	yeast 2-hybrid	10027300
PICK1	ACCN2	NO	in vitro;in vivo;yeast 2-hybrid	12578970 , 11802773 , 11739374
PICK1	EFNB2	NO	yeast 2-hybrid	15458844
PICK1	ARF1	NO	yeast 2-hybrid	10623590
PICK1	AQP1	NO	yeast 2-hybrid	10839360
PICK1	F11R	NO	in vivo	15811349
PICK1	ACCN1	NO	in vitro;in vivo;yeast 2-hybrid	11739374
PICK1	FXN	NO	yeast 2-hybrid	16713569
PICK1	GRIK1	NO	in vitro;in vivo;yeast 2-hybrid	12597860 , 11891216
PICK1	ARF3	NO	yeast 2-hybrid	10623590
PICK1	USP7	NO	yeast 2-hybrid	16713569
PICK1	PVRL4	NO	yeast 2-hybrid	15811349
PICK1	PRKCG	NO	yeast 2-hybrid	16713569
PICK1	COIL	NO	yeast 2-hybrid	16713569
PICK1	MLLT4	NO	in vivo	15811349
PICK1	PVRL2	NO	yeast 2-hybrid	15811349
PICK1	ATXN3	NO	yeast 2-hybrid	16713569
PICK1	GRIA2	NO	in vivo;yeast 2-hybrid	10027300
PICK1	CTNNB1	NO	in vivo	15811349
PICK1	APTX	NO	yeast 2-hybrid	16713569
PICK1	PRLHR	NO	in vitro;in vivo	11641419
PICK1	PRKCA	NO	in vitro;in vivo;yeast 2-hybrid	9405395
PICK1	BTG2	NO	in vitro;in vivo;yeast 2-hybrid	11237868
PICK1	SACS	YES	yeast 2-hybrid	16713569

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q12.3-13.32	chr22:31800000-49100000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)
22q13.1	chr22:37200000-40600000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 5)

Reference	ID in SZGene	Result Category
16380905	448	Negative
16314870	448	Positive
15305146	448	Positive
19158809	448	Negative
17367885	448	Negative

Gene relationship with MDD

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Region: chr22:38056311..38075701 View in gBrowse