Gene Report

Basic Info
Approved Symbol FGFR2
Previous Symbol KGFR, BEK, CFD1, JWS
Symbol Alias CEK3, TK14, TK25, ECT1, K-SAM, CD332
Approved Name fibroblast growth factor receptor 2
Previous Name bacteria-expressed kinase, "keratinocyte growth factor receptor", "craniofacial dysostosis 1", "Jackson-Weiss syndrome"
Name Alias Crouzon syndrome, "Pfeiffer syndrome"
Location 10q25.3-q26
Position chr10:121478334-121598458, -1
External Links HGNC: 3689
Entrez Gene: 2263
Ensembl: ENSG00000066468
UCSC: uc031wvw.1
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Xu, W., 2014 SNP: rs2981434 The SNP within or near this gene did not achieve genome-wide significance. Negative Comment on Study
Wang, T.,2012 SNP: rs11199993, rs17101921, rs17102287, rs2981427, rs2981578, rs2981581, rs3135730, rs7090018
Haplotype: rs7090018 - rs11199993(T-G), rs7090018 - rs11199993(T-C), rs7090018 - rs11199993(G-G), rs7090018 - rs11199993 (T-G ), rs7090018 - rs11199993 (T-C ), rs7090018 - rs11199993 (G-G )
Association between FGFR2 and BPD is worthy of further confirmation. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 129)

GO terms by PBA (count: 7)

GO terms by database search (count: 122)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 17)

Related other genetic factors
Gene related SNPs (count: 28)

Literature-origin SNPs (count: 9)

LD-proxies (count: 19)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 2)

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Region: chr10:121478334..121598458 View in gBrowse
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