Gene Report

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Basic Info

Approved Symbol	NTSR2
Symbol Alias	NTR2
Approved Name	neurotensin receptor 2
Location	2p25.1
Position	chr2:11658178-11670164, -1
External Links	HGNC: 8040 Entrez Gene: 23620 Ensembl: ENSG00000169006 UCSC: uc002rbq.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs4669765, rs7567183	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[9851594]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007600	sensory perception	biological process	TAS[8795617]	3
GO:0042391	regulation of membrane potential	biological process	IEA	13
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[9851594]	23
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[9851594]	26
GO:0007218	neuropeptide signaling pathway	biological process	IEA	18
GO:0016492	G-protein coupled neurotensin receptor activity	molecular function	IEA	1
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	IEA	11

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7567183	chr2:11671160 - 11671160(1)	downstream_gene_variant; upstream_gene_variant	1(1/0/0)
rs4669765	chr2:11668528 - 11668528(1)	intron_variant; upstream_gene_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p25.3-p25.1	chr2:0-12000000	1 (1/0/0)
2p25.3-25.1	chr2:0-12000000	1 (0/1/0)
2p25	chr2:0-12000000	3 (0/1/2)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
24391664	GPLS genes significantly dysregulated in anterior cingulate cortex by microarray	Pos	NTSR2

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Region: chr2:11658178..11670164 View in gBrowse