BDgene

Gene Report

Basic Info
Approved Symbol ADRBK2
Symbol Alias GRK3, BARK2
Approved Name adrenergic, beta, receptor kinase 2
Location 22q11
Position chr22:25564849-25729294, 1
External Links HGNC: 290
Entrez Gene: 157
Ensembl: ENSG00000100077
UCSC: uc003abx.4
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Barrett, T. B., 2007 Haplotype: GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15(), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(1-1-1-1-2), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(1-2-1-1-1), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(1-1-2-1-1), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(1-2-2-1-1), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(1-1-2-2-1), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(1-2-2-2-1), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(2-2-2-2-1), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(2-2-2-1-1), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(2-1-1-1-1), GRK3_SNP5 - GRK3_SNP6 - GRK3_2992_SNP14 - GRK3_SNP15 - GRK3_15401_SNP28(1-1-1-1-1)
Other variant: GRK3_129964_SNP37, GRK3_14087_SNP23, GRK3_14454_SNP24, GRK3_15401_SNP28, GRK3_15667_SNP29, GRK3_20256_SNP32, GRK3_2992_SNP14, GRK3_600_SNP12, GRK3_9046_SNP19, GRK3_SNP36
GRK3 might be associated with BPD, and a dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of BPD Positive Comment on Study
Prata, D. P., 2006 SNP: rs558934, rs5761116, rs576895 Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipolar affective disorder 1 in the Scottish population. Negative Comment on Study
Barrett, T. B.,2003 Haplotype: (GRK3_P-1) - (GRK3_P-5)()
Other variant: GRK3_P-2, GRK3_P-1, GRK3_P-5, GRK3_P-6
These data support the hypothesis that a dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of BPD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 8)

GO terms by PBA (count: 1)

GO terms by database search (count: 7)


Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)


Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 3)

Literature-origin SNPs (count: 3)

LD-proxies (count: 0)


Gene related CNVs (count: 1)

Gene related other variants (count: 14)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 4)


Gene relationship with MDD

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Region: chr22:25564849..25729294 View in gBrowse
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