Gene Report

Basic Info
Approved Symbol CNR1
Previous Symbol CNR
Symbol Alias CB1K5, CB-R, CB1, CANN6, CB1A
Approved Name cannabinoid receptor 1 (brain)
Location 6q14-q15
Position chr6:88139864-88166359, -1
External Links HGNC: 2159
Entrez Gene: 1268
Ensembl: ENSG00000118432
UCSC: uc003pmq.4
No. of Studies 5 (Positive: 0; Negative: 5; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fan, J., 2010 For gene-based test, P-value = 0.063 in STEP1. non-significant in any samples. Negative Comment on Study
Mansour, H. A.,2009 Gene-based tests:X<sup>2</sup>=4.971, P-value = 0.304 in recessive model, X<sup>2</sup>=3.233, P-value = 0.623 in dominant model, X<sup>2</sup>=2.629, P-value = 0.643 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Monteleone, P.,2010 SNP: rs1049353 A case-control study using the missense polymorphism, 2316A>G (Ile772Met), and the tetranucleotide repeat (TTTA)n showed no significant association with mood disorders in Japanese samples. Negative Comment on Study
Byrne, E. M., 2014 P-value=0.11. When ranking genes based on the most significant SNP, the strongest signal was rs9353523 in the CNR1 gene (P=0.001). Negative Comment on Study
Pisanu, C., 2013 SNP: rs806365, rs7766029, rs806366, rs806368, rs12720071, rs1049353, rs806374, rs806375, rs806376, rs6454672, rs9450898, rs806380 As a whole, our results do not support a clear role of CNR1 in BD and lithium response. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 39)

GO terms by PBA (count: 2)

GO terms by database search (count: 37)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 21)

Literature-origin SNPs (count: 12)

LD-proxies (count: 9)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 11)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 1)

View in gBrowse

Region: chr6:88139864..88166359 View in gBrowse
View in gBrowse