Gene Report

Basic Info
Approved Symbol APOE
Previous Symbol AD2
Approved Name apolipoprotein E
Previous Name Alzheimer disease 2 (APOE*E4-associated, late onset)
Location 19q13.31
Position chr19:44905754-44909393, 1
External Links HGNC: 613
Entrez Gene: 348
Ensembl: ENSG00000130203
UCSC: uc002pab.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Bellivier, F.,1997 Other variant: APOE_e3/e4 The association between epsilon4 and early onset bipolar disorder (BPD) with psychotic symptoms suggests that APO E gene is a risk factor for a subgroup of BPD, or influences the phenotypic expression (i.e. psychotic symptoms or age at onset) of manic depressive illness. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 138)

GO terms by PBA (count: 5)

GO terms by database search (count: 133)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 16)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 29)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 2)

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Region: chr19:44905754..44909393 View in gBrowse
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