Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	NDE1
Symbol Alias	nudE, FLJ20101, NDE
Approved Name	nudE neurodevelopment protein 1
Previous Name	nudE nuclear distribution gene E homolog 1 (A. nidulans), "nudE nuclear distribution E homolog 1 (A. nidulans)"
Location	16p13.11
Position	chr16:15643267-15726353, 1
External Links	HGNC: 17619 Entrez Gene: 54820 Ensembl: ENSG00000072864 UCSC: uc002dds.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kimura, H., 2014	Other variant: NDE1_Chr16:15785033_C/G, NDE1_Chr16:15785118_C/T, NDE1_Chr16:15785177_C/T	A signifiant association was detected between a variant within this gene and BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0019904	protein domain specific binding	molecular function	IEA	24

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051303	establishment of chromosome localization	biological process	IMP[17600710]	1
GO:0016477	cell migration	biological process	IBA	17
GO:0007020	microtubule nucleation	biological process	IBA	1
GO:0051298	centrosome duplication	biological process	ISS	3
GO:0005871	kinesin complex	cellular component	IBA	6
GO:0005515	protein binding	molecular function	IPI[16682949]	563
GO:0001764	neuron migration	biological process	IEA	18
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0007059	chromosome segregation	biological process	IBA	2
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS	15
GO:0005813	centrosome	cellular component	IDA[21399614]	34
GO:0000776	kinetochore	cellular component	IDA[17600710]	7
GO:0042802	identical protein binding	molecular function	IEA	44
GO:0005874	microtubule	cellular component	IEA	24
GO:0031616	spindle pole centrosome	cellular component	ISS	2
GO:0007100	mitotic centrosome separation	biological process	IBA	1
GO:0000777	condensed chromosome kinetochore	cellular component	IEA	7
GO:0008017	microtubule binding	molecular function	IBA; ISS	10
GO:0047496	vesicle transport along microtubule	biological process	IBA	5
GO:0005829	cytosol	cellular component	TAS	223
GO:0051642	centrosome localization	biological process	IBA	2
GO:0032154	cleavage furrow	cellular component	IEA	2
GO:0021987	cerebral cortex development	biological process	IMP[21529752]	9
GO:0006996	organelle organization	biological process	TAS	23
GO:0000132	establishment of mitotic spindle orientation	biological process	IMP[19468067]	2
GO:0007405	neuroblast proliferation	biological process	IEA	1
GO:0051301	cell division	biological process	IEA	20

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NDE1	ZNF365	YES	in vivo;yeast 2-hybrid	16682949
NDE1	MAPK1	NO	in vitro	12556484
NDE1	CDK1	NO	in vitro	12556484
NDE1	PAFAH1B1	NO	in vivo;yeast 2-hybrid	11163258
NDE1	TUBG1	NO	in vivo	11163258
NDE1	YWHAG	NO	in vivo	15324660

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_McQuillin[2011]_21	chr16:15435825-15889948 (NCBI Build 36 (hg18))	454124

Gene related other variants (count: 3)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
NDE1_Chr16:15785033_C/G	missense	Exon 7	1 (0/1/0)
NDE1_Chr16:15785118_C/T	missense	Exon 7	1 (0/1/0)
NDE1_Chr16:15785177_C/T	missense	Exon 7	1 (1/0/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)
16p12.3-p13.1	chr16:10400000-21200000	1 (1/0/0)
16p13	chr16:10400000-16700000	4 (1/0/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
25332407	This study strengthens the evidence for association between rare variants within NDE1 and SCZ, and may shed light into the molecular mechanisms underlying this severe psychiatric disorder.	Positive

Overlap with SZ from candidate gene intersection analysis (count: 4)

Reference	ID in SZGene	Result Category
17185386	150	Trend
18178387	150	Negative
20084519	150	Negative
18469341	150	Negative

Gene relationship with MDD

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Region: chr16:15643267..15726353 View in gBrowse