Gene Report

Approved Symbol	GRM3
Symbol Alias	GPRC1C, mGlu3, MGLUR3
Approved Name	glutamate receptor, metabotropic 3
Location	7q21.1-q21.2
Position	chr7:86643914-86864884, 1
External Links	HGNC: 4595 Entrez Gene: 2913 Ensembl: ENSG00000198822 UCSC: uc003uid.3
No. of Studies	7 (Positive: 3; Negative: 4; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kandaswamy R, 2013	SNP: rs2237563, rs274621, rs2158786	Genetic markers at the gene encoding the metabotropic glutamate receptor 3 (GRM3) showed allelic association with bipolar disorder.	Positive	Comment on Study
Dalvie, S.,2010	SNP: rs6465084	There were no significant difference in SNP allele frequencies between cases and controls.	Negative	Comment on Study
Marti, S. B.,2002	Other variant: GRM3_+1131C/T	In conclusion, our preliminary data suggest that genetic variation in the GRM3 gene does not seem to play a role in the development of bipolar disorder in the German population.	Negative	Comment on Study
Yosifova, A.,2009	SNP: rs1024516, rs1405874, rs17126, rs2189813, rs2237554, rs2237555, rs2299213, rs982339	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Fallin, M. D.,2005		10 SNP typed, Median D'=0.77, Median r<sup>2</sup> =0.15, 3 LD blocks, 0.78 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP.. This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Positive	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0012. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study
Tsunoka, T.,2009	SNP: rs6465084	We did not find any association between GRM3 and BP in the allele/genotype-wise analysis.	Negative	Comment on Study

Region: chr7:86643914..86864884 View in gBrowse