Gene Report

Basic Info
Approved Symbol GRM3
Symbol Alias GPRC1C, mGlu3, MGLUR3
Approved Name glutamate receptor, metabotropic 3
Location 7q21.1-q21.2
Position chr7:86643914-86864884, 1
External Links HGNC: 4595
Entrez Gene: 2913
Ensembl: ENSG00000198822
UCSC: uc003uid.3
No. of Studies 7 (Positive: 3; Negative: 4; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 7)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kandaswamy R, 2013 SNP: rs2237563, rs274621, rs2158786 Genetic markers at the gene encoding the metabotropic glutamate receptor 3 (GRM3) showed allelic association with bipolar disorder. Positive Comment on Study
Dalvie, S.,2010 SNP: rs6465084 There were no significant difference in SNP allele frequencies between cases and controls. Negative Comment on Study
Marti, S. B.,2002 Other variant: GRM3_+1131C/T In conclusion, our preliminary data suggest that genetic variation in the GRM3 gene does not seem to play a role in the development of bipolar disorder in the German population. Negative Comment on Study
Yosifova, A.,2009 SNP: rs1024516, rs1405874, rs17126, rs2189813, rs2237554, rs2237555, rs2299213, rs982339 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Fallin, M. D.,2005 10 SNP typed, Median D'=0.77, Median r<sup>2</sup> =0.15, 3 LD blocks, 0.78 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP.. This gene is highly suggestive to BP , not suggestive to SZ/SZA. Positive Comment on Study
Johnson, C.,2009 Monte-Carlo Simulation P-value = 0.0012. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis Positive Comment on Study
Tsunoka, T.,2009 SNP: rs6465084 We did not find any association between GRM3 and BP in the allele/genotype-wise analysis. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 17)

GO terms by PBA (count: 5)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 88)

Literature-origin SNPs (count: 12)

LD-proxies (count: 76)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 16)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 4)

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Region: chr7:86643914..86864884 View in gBrowse
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