Gene Report

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Basic Info

Approved Symbol	CTNNA3
Symbol Alias	VR22, MGC26194
Approved Name	catenin (cadherin-associated protein), alpha 3
Location	10q21
Position	chr10:65912518-67696169, -1
External Links	HGNC: 2511 Entrez Gene: 29119 Ensembl: ENSG00000183230 UCSC: uc001jmw.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051015	actin filament binding	molecular function	IEA	9
GO:0045296	cadherin binding	molecular function	TAS[11590244]	7

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030027	lamellipodium	cellular component	IEA	9
GO:0086091	regulation of heart rate by cardiac conduction	biological process	IMP[23136403]	6
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0098911	regulation of ventricular cardiac muscle cell action potential	biological process	IMP[23136403]	3
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0008013	beta-catenin binding	molecular function	IPI[23136403]	14
GO:0005916	fascia adherens	cellular component	IDA[11590244]	4
GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	molecular function	IMP[23136403]	2
GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	biological process	IMP[23136403]	2
GO:0005515	protein binding	molecular function	IPI[11590244]	563
GO:0016337	single organismal cell-cell adhesion	biological process	IPI[11590244]	10

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04530	Tight junction	18

ID	Name	No. of Genes in BDgene
hsa04520	Adherens junction	11
hsa05213	Endometrial cancer	10
hsa04670	Leukocyte transendothelial migration	13

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
cell2cellPathway	Cell to Cell Adhesion Signaling	2

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CTNNA3	CTNNB1	NO	in vivo	11590244

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Kember[2015]_23	chr10:68239474-68422442 (UCSC build 37, hg19)	182969		deletion
CNV_Abdul Noor[2014]_13	chr10:68825642-68977724 (NCBI Build 36/hg18)	152000	10q21.3	duplication

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11.21-q22.1	chr10:34200000-73100000	1 (1/0/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q11.21-q22.1	chr10:41600000-73100000	1 (0/0/1)
10q11-q21	chr10:39800000-68800000	1 (0/1/0)
10q21	chr10:51100000-68800000	4 (0/3/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:65912518..67696169 View in gBrowse