Gene Report

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Basic Info

Approved Symbol	FMO5
Approved Name	flavin containing monooxygenase 5
Location	1q21.1
Position	chr1:147175351-147243050, -1
External Links	HGNC: 3773 Entrez Gene: 2330 Ensembl: ENSG00000131781 UCSC: uc001epi.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008150	biological_process	biological process	ND	24
GO:0050660	flavin adenine dinucleotide binding	molecular function	IEA	5
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA	52
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0050661	NADP binding	molecular function	IEA	5
GO:0004499	N,N-dimethylaniline monooxygenase activity	molecular function	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00982	Drug metabolism - cytochrome P450	6

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_1	chr1:144943150-146293282 (NCBI Build 36/hg18)	1	1q21.1	duplication

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p13.2-1q21.3	chr1:111200000-155100000	1 (1/0/0)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr1:147175351..147243050 View in gBrowse