Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	NMUR2
Previous Symbol	NMU2R
Approved Name	neuromedin U receptor 2
Location	5q33.1
Position	chr5:152391532-152433368, -1
External Links	HGNC: 16454 Entrez Gene: 56923 Ensembl: ENSG00000132911 UCSC: uc003luv.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bergen, S. E.,2012	SNP: rs4262150	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007417	central nervous system development	biological process	IEP[10899166]	21
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IDA[10899166]	219
GO:0006816	calcium ion transport	biological process	IDA[10899166]	14

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0048016	inositol phosphate-mediated signaling	biological process	IDA[10899166]	1
GO:0050482	arachidonic acid secretion	biological process	IDA[10887190]	8
GO:1902476	chloride transmembrane transport	biological process	IDA[10899166]	16
GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling	biological process	IDA[10899166]	2
GO:0019722	calcium-mediated signaling	biological process	NAS[10899166]	9
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0005525	GTP binding	molecular function	IDA[10899166]	20
GO:0048265	response to pain	biological process	IEA	8
GO:0005229	intracellular calcium activated chloride channel activity	molecular function	IDA[10899166]	3
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[10894543]	26
GO:0006940	regulation of smooth muscle contraction	biological process	NAS[10887190]	5
GO:0042924	neuromedin U binding	molecular function	IDA[10899166]	1
GO:0007625	grooming behavior	biological process	IEA	5
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	IDA[10899166]	11
GO:0006821	chloride transport	biological process	IDA[10899166]	4
GO:0007267	cell-cell signaling	biological process	TAS[10894543]	29
GO:0002023	reduction of food intake in response to dietary excess	biological process	IEA	1
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IDA[10899166]	21
GO:0007631	feeding behavior	biological process	TAS[10894543]	12
GO:0001607	neuromedin U receptor activity	molecular function	IDA[10887190]	1
GO:0007218	neuropeptide signaling pathway	biological process	IEA	18

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NMUR2	NMU	YES	in vitro;in vivo	10894543 , 10899166 , 10887190

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4262150	chr5:152908893 - 152908893(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q31-q33	chr5:131200000-160500000	1 (1/0/0)
5q32-5q33.3	chr5:145100000-160500000	1 (0/1/0)
5q33	chr5:150400000-160500000	2 (0/1/1)
5q33-34	chr5:150400000-169000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
22688191	No significant association was observed in SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr5:152391532..152433368 View in gBrowse