Gene Report

Basic Info
Approved Symbol PCDH15
Previous Symbol USH1F, DFNB23
Symbol Alias CDHR15
Approved Name protocadherin-related 15
Previous Name deafness, autosomal recessive 23, "protocadherin 15"
Name Alias cadherin-related family member 15
Location 10q21.1
Position chr10:53802771-55627942, -1
External Links HGNC: 14674
Entrez Gene: 65217
Ensembl: ENSG00000150275
UCSC: uc010qhy.1
No. of Studies 4 (Positive: 2; Negative: 1; trend: 1)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Noor A., 2014 Selected stringent CNV related to this gene is validated by qPCR from BD case data. Positive Comment on Study
Hattori, E.,2009 SNP: rs1059016, rs1414686 After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. Positive Comment on Study
Djurovic, S.,2010 SNP: rs7081438, rs7100273, rs825795 No significant association of this gene was observed in BD. Negative Comment on Study
Georgieva, L., 2014 The loci in this gene impacted by de novo CNVs have been previously implicated in neuropsychiatric disorders, which enhance their credibility as candidates for BD. Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 4)

GO terms by database search (count: 9)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 11)

Literature-origin SNPs (count: 5)

LD-proxies (count: 6)

Gene related CNVs (count: 3)

Gene related other variants (count: 0)

Gene related regions (count: 6)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:53802771..55627942 View in gBrowse
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