Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	VAMP7
Previous Symbol	SYBL1
Symbol Alias	VAMP-7, TI-VAMP
Approved Name	vesicle-associated membrane protein 7
Previous Name	synaptobrevin-like 1
Location	Xq28 and Yq12
Position	chrX:155881293-155943769, 1
External Links	HGNC: 11486 Entrez Gene: 6845 Ensembl: ENSG00000124333 UCSC: uc004fns.3
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Saito, T.,2000	Other variant: SYBL1_intron5_G>C	No significant association was observed in BD.	Negative	Comment on Study
Muller, D. J.,2002	Other variant: SYBL1_intron5_G>C	Statistical analyses revealed no overall allele or genotype associations with the disease.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 51)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[18253931]; TAS	360
GO:0045202	synapse	cellular component	IEA	29
GO:0016020	membrane	cellular component	IDA[16677249]	137
GO:0016021	integral component of membrane	cellular component	IEA	219

GO terms by database search (count: 47)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045335	phagocytic vesicle	cellular component	ISS[15470500]	4
GO:0006892	post-Golgi vesicle-mediated transport	biological process	TAS	4
GO:1903595	positive regulation of histamine secretion by mast cell	biological process	IMP[18253931]	2
GO:0016192	vesicle-mediated transport	biological process	IDA[10888671]	10
GO:0043312	neutrophil degranulation	biological process	IMP[16677249]; ISS[14993220]	2
GO:0035493	SNARE complex assembly	biological process	IEA	2
GO:0043308	eosinophil degranulation	biological process	IMP[16677249]; ISS[14993220]	2
GO:0000046	autophagic vacuole fusion	biological process	IMP[23217709]	2
GO:0005789	endoplasmic reticulum membrane	cellular component	ISS[16495485]	52
GO:0045177	apical part of cell	cellular component	IEA	13
GO:0030027	lamellipodium	cellular component	IDA[22589474]	9
GO:0031143	pseudopodium	cellular component	IDA[22589474]	2
GO:0030658	transport vesicle membrane	cellular component	IEA	4
GO:0000149	SNARE binding	molecular function	IBA	7
GO:0048280	vesicle fusion with Golgi apparatus	biological process	IEA	2
GO:0061024	membrane organization	biological process	TAS	14
GO:0006906	vesicle fusion	biological process	IDA[10888671]	4
GO:0034197	triglyceride transport	biological process	IEA	1
GO:0005802	trans-Golgi network	cellular component	IDA[19745841]	10
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	34
GO:0031201	SNARE complex	cellular component	IDA[18253931]; ISS[15133481]	8
GO:0006887	exocytosis	biological process	IBA	6
GO:0043001	Golgi to plasma membrane protein transport	biological process	IEA	6
GO:0009986	cell surface	cellular component	IEA	40
GO:0031091	platelet alpha granule	cellular component	IDA[22589474]	1
GO:0043005	neuron projection	cellular component	ISS	38
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	50
GO:0005484	SNAP receptor activity	molecular function	IBA	6
GO:0030667	secretory granule membrane	cellular component	IDA[16677249]	4
GO:0030054	cell junction	cellular component	IEA	88
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	ISS[16495485]	6
GO:0017156	calcium ion-dependent exocytosis	biological process	ISS[14993220]	5
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0043320	natural killer cell degranulation	biological process	IMP[18042464]	2
GO:0035577	azurophil granule membrane	cellular component	IDA[16677249]	1
GO:0005765	lysosomal membrane	cellular component	IDA[17897319]; ISS[10459012]; TAS	14
GO:0006897	endocytosis	biological process	IBA	15
GO:0006911	phagocytosis, engulfment	biological process	ISS[15133481]	1
GO:0019905	syntaxin binding	molecular function	IEA	5
GO:0008333	endosome to lysosome transport	biological process	IDA[10888671]	4
GO:0031902	late endosome membrane	cellular component	ISS[10459012]	5
GO:0030670	phagocytic vesicle membrane	cellular component	IEA	6
GO:0030141	secretory granule	cellular component	IDA[18042464]	14
GO:1900483	regulation of protein targeting to vacuolar membrane	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[16354670]	563

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04130	SNARE interactions in vesicular transport	7

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
VAMP7	STX1A	NO	in vitro;in vivo	12853575
VAMP7	DNAJC5	NO	in vitro	15610015
VAMP7	AP3D1	NO	in vitro;in vivo;yeast 2-hybrid	12853575 , 18775314
VAMP7	STX7	NO	in vitro;in vivo	11278762 , 12175335
VAMP7	STX4	NO	in vivo	14993220
VAMP7	SNAP25	YES	in vitro;in vivo	12853575
VAMP7	AGFG1	NO	in vitro;in vivo;yeast 2-hybrid	18775314
VAMP7	STX3	NO	in vitro	9614185
VAMP7	SNAP23	NO	in vitro	9614185

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
SYBL1_intron5_G>C	point mutation	intron5	2 (0/2/0)

Gene related regions (count: 0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chrX:155881293..155943769 View in gBrowse