Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	DPP10
Symbol Alias	DPRP3
Approved Name	dipeptidyl-peptidase 10 (non-functional)
Previous Name	dipeptidylpeptidase 10, "dipeptidyl-peptidase 10"
Location	2q14.1
Position	chr2:114442299-115845752, 1
External Links	HGNC: 20823 Entrez Gene: 57628 Ensembl: ENSG00000175497 UCSC: uc002tle.3
No. of Studies	3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 3)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs1847694, rs10180987 Other variant: DPP10_Chr2:116251310, DPP10_Chr2:116314867	Significant association of SNP in this gene with BD was observed.	Positive	Comment on Study
Ollila, H. M.,2009	SNP: rs1375144	It showed no evidence for association with BPI in our study.	Negative	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00032, Product of P truncation <=0.01=0.00019, Product of P truncation <=0.001=0.00011. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008239	dipeptidyl-peptidase activity	molecular function	IDA[12662155]	3
GO:0005886	plasma membrane	cellular component	ISS	360
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0016020	membrane	cellular component	IDA[12662155]	137

GO terms by database search (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0015459	potassium channel regulator activity	molecular function	ISS	11
GO:0090004	positive regulation of establishment of protein localization to plasma membrane	biological process	IDA[15671030]	6
GO:0006508	proteolysis	biological process	IEA	34
GO:1901379	regulation of potassium ion transmembrane transport	biological process	ISS	4
GO:0008236	serine-type peptidase activity	molecular function	IEA	9
GO:0072659	protein localization to plasma membrane	biological process	ISS	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 46)

Literature-origin SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11123306	chr2:115474205 - 115474205(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/0/1)
rs1375144	chr2:115483610 - 115483610(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	3(0/1/2)
rs10180987	chr2:115365856 - 115365856(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)
rs6741692	chr2:115546355 - 115546355(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/0/1)
rs1847694	chr2:114247557 - 114247557(1)		1(1/0/0)
rs2421104	chr2:115484689 - 115484689(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/0/1)

LD-proxies (count: 40)

rs_ID	Location	Functional Annotation
rs1823268	chr2:115541387 - 115541387(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12618777	chr2:115545269 - 115545269(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12990349	chr2:115557547 - 115557547(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12997176	chr2:115557686 - 115557686(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7583158	chr2:115523681 - 115523681(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs950586	chr2:115440072 - 115440072(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs965536	chr2:115444772 - 115444772(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs708647	chr2:115440181 - 115440181(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs843435	chr2:115466223 - 115466223(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs1712000	chr2:115471440 - 115471440(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs13027270	chr2:115458007 - 115458007(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs843422	chr2:115459966 - 115459966(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs6732466	chr2:115475684 - 115475684(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2121998	chr2:115476391 - 115476391(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs10496492	chr2:115473499 - 115473499(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1597193	chr2:115474799 - 115474799(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4313982	chr2:115484551 - 115484551(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs10496494	chr2:115485693 - 115485693(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1037205	chr2:115481602 - 115481602(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs13027502	chr2:115482073 - 115482073(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs10496497	chr2:115486336 - 115486336(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4383330	chr2:115487049 - 115487049(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs10496496	chr2:115485909 - 115485909(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1530689	chr2:115486171 - 115486171(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4849399	chr2:115490145 - 115490145(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4849398	chr2:115490043 - 115490043(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1584400	chr2:115489750 - 115489750(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1584401	chr2:115489649 - 115489649(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4848392	chr2:115494765 - 115494765(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs13030726	chr2:115492547 - 115492547(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1448455	chr2:115492352 - 115492352(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1550986	chr2:115492077 - 115492077(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs13002613	chr2:115506172 - 115506172(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs10185860	chr2:115500972 - 115500972(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2029035	chr2:115495330 - 115495330(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2421105	chr2:115495033 - 115495033(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7584395	chr2:115532152 - 115532152(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2901338	chr2:115516829 - 115516829(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs969255	chr2:115512105 - 115512105(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs11690107	chr2:115507253 - 115507253(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
DPP10_Chr2:116251310		Exonic	1 (0/0/1)
DPP10_Chr2:116314867		Exonic	1 (0/0/1)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr2:114442299..115845752 View in gBrowse