Gene Report

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Basic Info

Approved Symbol	FAAH
Symbol Alias	FAAH-1
Approved Name	fatty acid amide hydrolase
Location	1p35-p34
Position	chr1:46394265-46413848, 1
External Links	HGNC: 3553 Entrez Gene: 2166 Ensembl: ENSG00000117480 UCSC: uc001cpu.2
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Pisanu, C., 2013	SNP: rs17361936, rs6429600, rs4141964, rs324420, rs324419, rs11576941	As a whole, our results do not support a clear role of FAAH in BD and lithium response.	Negative	Comment on Study
Monteleone, P.,2010	SNP: rs324420	A case-control study using the missense polymorphism, 2316A>G (Ile772Met), and the tetranucleotide repeat (TTTA)n showed no significant association with mood disorders in Japanese samples.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031090	organelle membrane	cellular component	ISS	1
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	molecular function	IEA	1
GO:0047372	acylglycerol lipase activity	molecular function	IEA	1
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0017064	fatty acid amide hydrolase activity	molecular function	IDA[9122178]	1
GO:0012505	endomembrane system	cellular component	IEA	9
GO:0009062	fatty acid catabolic process	biological process	IDA[9122178]	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 16)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4141964	chr1:46399368 - 46399368(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs6429600	chr1:46398839 - 46398839(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs324420	chr1:46405089 - 46405089(1)	missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	2(0/2/0)
rs324419	chr1:46406314 - 46406314(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant; upstream_gene_variant	1(0/1/0)
rs17361936	chr1:46397221 - 46397221(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs11576941	chr1:46409395 - 46409395(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs3766246	chr1:46399999 - 46399999(1)	intron_variant; non_coding_transcript_variant
rs2295633	chr1:46408711 - 46408711(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs6662982	chr1:46411508 - 46411508(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12029329	chr1:46414184 - 46414184(1)	downstream_gene_variant
rs6703669	chr1:46396883 - 46396883(1)	intron_variant; non_coding_transcript_variant
rs2145408	chr1:46396235 - 46396235(1)	intron_variant; non_coding_transcript_variant
rs17361950	chr1:46398478 - 46398478(1)	intron_variant; non_coding_transcript_variant
rs324418	chr1:46407026 - 46407026(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs6703374	chr1:46396660 - 46396660(1)	intron_variant; non_coding_transcript_variant
rs1984490	chr1:46393062 - 46393062(1)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p33-p36	chr1:0-50200000	1 (0/0/1)
1p33	chr1:46300000-50200000	2 (0/0/2)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
15721218	241	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20080186	A case-control study using the missense polymorphism, 2316A>G (Ile772Met), and the tetranucleotide repeat (TTTA)n showed no significant association with mood disorders in Japanese samples.	Negative

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Region: chr1:46394265..46413848 View in gBrowse