Gene Report

Basic Info
Approved Symbol AKR1D1
Previous Symbol SRD5B1
Approved Name aldo-keto reductase family 1, member D1
Previous Name aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
Name Alias delta 4-3-ketosteroid-5-beta-reductase
Location 7q32-q33
Position chr7:138002324-138117986, 1
External Links HGNC: 388
Entrez Gene: 6718
Ensembl: ENSG00000122787
UCSC: uc003vtz.3
No. of Studies 2 (Positive: 0; Negative: 1; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Goes, F. S.,2012 SNP: rs10255295 OR = 1.31,P-value(Meta) = 0.00000473 Suggestive association was found. Trend Comment on Study
Steen, N. E.,2010 SNP: rs12668157, rs2306847, rs6467734 No significant association of AKR1D1 was observed in BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 2)

GO terms by database search (count: 11)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 28)

Literature-origin SNPs (count: 4)

LD-proxies (count: 24)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr7:138002324..138117986 View in gBrowse
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