Gene Report

Basic Info
Approved Symbol NEK4
Previous Symbol STK2
Symbol Alias NRK2, pp12301
Approved Name NIMA-related kinase 4
Previous Name serine/threonine kinase 2, "NIMA (never in mitosis gene a)-related kinase 4"
Name Alias serine/threonine protein kinase-2
Location 3p21.1
Position chr3:52708449-52770949, -1
External Links HGNC: 11399
Entrez Gene: 6787
Ensembl: ENSG00000114904
UCSC: uc003dfq.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Moskvina, V.,2009 In BD:Smallest P-value per gene=0.00636, Product of P truncation <=0.01=0.00346, Product of P truncation <=0.001=NA. It showed evidence for association with BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 17)

GO terms by PBA (count: 1)

GO terms by database search (count: 16)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 33)

Literature-origin SNPs (count: 1)

LD-proxies (count: 32)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr3:52708449..52770949 View in gBrowse
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