Gene Report

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Basic Info

Approved Symbol	FABP7
Symbol Alias	B-FABP, BLBP
Approved Name	fatty acid binding protein 7, brain
Name Alias	brain lipid binding protein
Location	6q22-q23
Position	chr6:122779475-122784074, 1
External Links	HGNC: 3562 Entrez Gene: 2173 Ensembl: ENSG00000164434 UCSC: uc003pzf.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Iwayama, Y., 2010	SNP: rs12662030, rs2279381, rs2279382, rs4247671, rs6899351, rs6904500, rs6919681, rs7752838, rs9372716, rs9401594, rs9401595, rs9401596, rs9482286, rs9490550 Haplotype: rs2279382 - rs2279381 - rs7752838(TCA), rs2279382 - rs2279381 - rs7752838(TCG), rs2279382 - rs2279381 - rs7752838(GTG), rs2279382 - rs2279381 - rs7752838(GCG), rs4247671 - rs12662030 - rs9372716(AAT), rs4247671 - rs12662030 - rs9372716(AAC), rs4247671 - rs12662030 - rs9372716(ACC), rs4247671 - rs12662030 - rs9372716(GAC), rs6899351 - rs6919681 - rs6904500(TAT), rs6899351 - rs6919681 - rs6904500(TAC), rs6899351 - rs6919681 - rs6904500(TGC), rs6899351 - rs6919681 - rs6904500(CGC), rs9490550 - rs9401596(TG), rs9490550 - rs9401596(GA), rs9490550 - rs9401596(GG)	Three single nucleotide polymorphisms (SNPs) from FABP7 showed nominal association with bipolar disorder, and haplotypes of the same gene showed empirical associations with bipolar disorder even after correction of multiple testing.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0007399	nervous system development	biological process	TAS[9375786]	40

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0050673	epithelial cell proliferation	biological process	IEA	1
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0008285	negative regulation of cell proliferation	biological process	TAS[9250612]	41
GO:0022008	neurogenesis	biological process	IEA	4
GO:0021846	cell proliferation in forebrain	biological process	IEA	2
GO:0006810	transport	biological process	IEA	47
GO:0042995	cell projection	cellular component	IEA	9
GO:0008289	lipid binding	molecular function	IEA	8
GO:0005215	transporter activity	molecular function	IEA	8
GO:0060134	prepulse inhibition	biological process	IEA	8

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa03320	PPAR signaling pathway	4

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 16)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs9401595	chr6:122782670 - 122782670(1)	3_prime_UTR_variant; intron_variant	1(1/0/0)
rs6904500	chr6:122788451 - 122788451(1)	downstream_gene_variant; upstream_gene_variant	1(0/1/0)
rs12662030	chr6:122771130 - 122771130(1)		1(0/1/0)
rs9372716	chr6:122771214 - 122771214(1)		1(1/0/0)
rs9401596	chr6:122783558 - 122783558(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs9401594	chr6:122782340 - 122782340(1)	3_prime_UTR_variant; intron_variant	1(0/1/0)
rs2279381	chr6:122780399 - 122780399(1)	missense_variant	1(0/1/0)
rs6899351	chr6:122787961 - 122787961(1)	downstream_gene_variant; upstream_gene_variant	1(0/1/0)
rs7752838	chr6:122782331 - 122782331(1)	3_prime_UTR_variant; intron_variant	1(0/1/0)
rs6919681	chr6:122788180 - 122788180(1)	downstream_gene_variant; upstream_gene_variant	1(0/1/0)
rs2279382	chr6:122780228 - 122780228(1)	intron_variant	1(1/0/0)
rs9490550	chr6:122783162 - 122783162(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs4247671	chr6:122770347 - 122770347(1)		1(0/1/0)
rs9482286	chr6:122786552 - 122786552(1)	downstream_gene_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs9490549		chr6:122783060 - 122783060(1)	downstream_gene_variant; intron_variant
rs2243372		chr6:122780502 - 122780502(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q22.1-6q22.33	chr6:114200000-130000000	1 (0/1/0)
6q21-22	chr6:105000000-130000000	1 (0/0/1)
6q22	chr6:114200000-130000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:122779475..122784074 View in gBrowse