Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	LAMA3
Previous Symbol	LAMNA
Symbol Alias	nicein-150kDa, kalinin-165kDa, BM600-150kDa, epiligrin
Approved Name	laminin, alpha 3
Previous Name	laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)
Location	18q11.2
Position	chr18:23689443-23955066, 1
External Links	HGNC: 6483 Entrez Gene: 3909 Ensembl: ENSG00000053747 UCSC: uc002kuq.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs17202961	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005198	structural molecule activity	molecular function	NAS[8586427]	14
GO:0007155	cell adhesion	biological process	IEA	42
GO:0005102	receptor binding	molecular function	IEA	37

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008544	epidermis development	biological process	TAS[8586427]	7
GO:0005604	basement membrane	cellular component	TAS[8586427]	5
GO:0022617	extracellular matrix disassembly	biological process	TAS	10
GO:0005610	laminin-5 complex	cellular component	IEA	1
GO:0005606	laminin-1 complex	cellular component	IEA	2
GO:0031581	hemidesmosome assembly	biological process	TAS	2
GO:0005576	extracellular region	cellular component	TAS	97
GO:0045995	regulation of embryonic development	biological process	IEA	2
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23533145]	176
GO:0034329	cell junction assembly	biological process	TAS	8
GO:0030334	regulation of cell migration	biological process	IEA	9
GO:0035987	endodermal cell differentiation	biological process	IEP[23154389]	3
GO:0030155	regulation of cell adhesion	biological process	IEA	3
GO:0030198	extracellular matrix organization	biological process	TAS	26

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 3)

ID	Name	No. of Genes in BDgene
hsa04510	Focal adhesion	22
hsa04512	ECM-receptor interaction	9
hsa05222	Small cell lung cancer	8

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa01430	Cell Communication	11

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
agrPathway	Agrin in Postsynaptic Differentiation	8

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
LAMA3	BMP1	NO	in vitro;in vivo	10806203
LAMA3	PLAT	NO	in vitro	10956663
LAMA3	PLG	NO	in vitro	10956663
LAMA3	SDC2	NO	in vitro	11373281
LAMA3	LAMB3	NO	in vitro	7775432
LAMA3	SLC35E1	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 27)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17202961	chr18:23845027 - 23845027(1)	missense_variant	1(0/0/1)
rs12608087	chr18:23816593 - 23816593(1)	intron_variant	1(0/1/0)

LD-proxies (count: 25)

rs_ID	Location	Functional Annotation
rs1541836	chr18:23915519 - 23915519(1)	intron_variant; non_coding_transcript_variant
rs734731	chr18:23910070 - 23910070(1)	intron_variant; non_coding_transcript_variant
rs3786412	chr18:23922100 - 23922100(1)	intron_variant; non_coding_transcript_variant
rs984806	chr18:23950702 - 23950702(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs9952967	chr18:23944586 - 23944586(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs11082864	chr18:23955167 - 23955167(1)	downstream_gene_variant
rs2288593	chr18:23951548 - 23951548(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs7244776	chr18:23790563 - 23790563(1)	intron_variant
rs4800168	chr18:23791852 - 23791852(1)	intron_variant
rs6507907	chr18:23773387 - 23773387(1)	intron_variant
rs8086477	chr18:23775212 - 23775212(1)	intron_variant
rs1941518	chr18:23828784 - 23828784(1)	intron_variant; non_coding_transcript_variant
rs7242115	chr18:23835810 - 23835810(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs9950679	chr18:23814751 - 23814751(1)	intron_variant
rs1941519	chr18:23826062 - 23826062(1)	intron_variant; upstream_gene_variant
rs8096915	chr18:23865877 - 23865877(1)	intron_variant
rs11082838	chr18:23904280 - 23904280(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs12607408	chr18:23843018 - 23843018(1)	intron_variant
rs9955402	chr18:23848072 - 23848072(1)	intron_variant
rs12456706	chr18:23926875 - 23926875(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs8089138	chr18:23943099 - 23943099(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs12607787	chr18:23916202 - 23916202(1)	intron_variant; non_coding_transcript_variant
rs2014437	chr18:23925630 - 23925630(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs12458632	chr18:23922412 - 23922412(1)	intron_variant; non_coding_transcript_variant
rs7230939	chr18:23753554 - 23753554(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
18p11-q12.3	chr18:0-45900000	1 (0/0/1)
18q	chr18:18500000-80373285	1 (0/1/0)
Chr 18	chr18:0-80373285	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr18:23689443..23955066 View in gBrowse