Gene Report

Basic Info
Approved Symbol CHRNA3
Approved Name cholinergic receptor, nicotinic, alpha 3 (neuronal)
Previous Name cholinergic receptor, nicotinic, alpha polypeptide 3
Name Alias acetylcholine receptor, nicotinic, alpha 3 (neuronal)
Location 15q24
Position chr15:78593052-78621295, -1
External Links HGNC: 1957
Entrez Gene: 1136
Ensembl: ENSG00000080644
UCSC: uc002bec.3
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Shi, J., 2007 SNP: rs11637630, rs6495309 no evidence of interaction among these 19 cholinergic genes was found by Allelic Association, Haploview Tests, FITF analysis and FDR correction Negative Comment on Study
Jackson, K. J., 2013 SNP: rs1051730, rs8040868 Variants in the 15q25 gene cluster are associated with risk for schizophrenia/bipolar illness, negative symptoms of schizophrenia, and influence CHRNA5 expression in the brain and peripheral blood mononuclear cells. Positive Comment on Study
Hartz, S. M.,2011 SNP: rs1051730, rs3743078, rs578776 No significant associations were detected in BD patients. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 28)

GO terms by PBA (count: 6)

GO terms by database search (count: 22)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 31)

Literature-origin SNPs (count: 10)

LD-proxies (count: 21)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr15:78593052..78621295 View in gBrowse
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