Gene Report

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Basic Info

Approved Symbol	MGAT4A
Symbol Alias	GnT-Iva, GnT-4a
Approved Name	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
Previous Name	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A
Location	2q12
Position	chr2:98619106-98731126, -1
External Links	HGNC: 7047 Entrez Gene: 11320 Ensembl: ENSG00000071073 UCSC: uc002sze.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2011	SNP: rs12618769, rs7560357	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:0043687	post-translational protein modification	biological process	TAS	9
GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular function	IEA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19199708]	176
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS	5
GO:0006491	N-glycan processing	biological process	TAS[10024668]	2
GO:0000139	Golgi membrane	cellular component	TAS	36

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00510	N-Glycan biosynthesis	3
hsa01030	Glycan structures - biosynthesis 1	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 7)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7560357	chr2:98631357 - 98631357(1)	intron_variant	1(0/0/1)
rs12618769	chr2:98623468 - 98623468(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs17513468	chr2:98618706 - 98618706(1)	downstream_gene_variant
rs3769698	chr2:98617431 - 98617431(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs1516085	chr2:98615849 - 98615849(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs4851146	chr2:98620976 - 98620976(1)	3_prime_UTR_variant; downstream_gene_variant
rs11892744	chr2:98621329 - 98621329(1)	3_prime_UTR_variant; downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p16.1-q11.2	chr2:54700000-102100000	1 (1/0/0)
2q11	chr2:93900000-102100000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:98619106..98731126 View in gBrowse