Gene Report

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Basic Info

Approved Symbol	PLCL2
Previous Symbol	PLCE2
Symbol Alias	KIAA1092
Approved Name	phospholipase C-like 2
Previous Name	phospholipase C, epsilon 2
Location	3p24.3
Position	chr3:16802651-17090594, 1
External Links	HGNC: 9064 Entrez Gene: 23228 Ensembl: ENSG00000154822 UCSC: uc032rgc.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs12485389	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004871	signal transducer activity	molecular function	IEA	32

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006629	lipid metabolic process	biological process	IEA	10
GO:0050811	GABA receptor binding	molecular function	IDA[16754670]	2
GO:0033135	regulation of peptidyl-serine phosphorylation	biological process	IEA	1
GO:0005737	cytoplasm	cellular component	IEA	322
GO:1900122	positive regulation of receptor binding	biological process	IEA	2
GO:0007214	gamma-aminobutyric acid signaling pathway	biological process	IEA	15
GO:0002322	B cell proliferation involved in immune response	biological process	IEA	2
GO:0002337	B-1a B cell differentiation	biological process	IEA	1
GO:0032228	regulation of synaptic transmission, GABAergic	biological process	IEA	5
GO:0035556	intracellular signal transduction	biological process	IEA	38
GO:0004435	phosphatidylinositol phospholipase C activity	molecular function	IEA	8
GO:0050859	negative regulation of B cell receptor signaling pathway	biological process	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PLCL2	PPP1CA	NO	yeast 2-hybrid	15231748
PLCL2	DSCAML1	NO	yeast 2-hybrid	12421765

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs12485389	chr3:16876050 - 16876050(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs6796746		chr3:16843728 - 16843728(1)	intron_variant; non_coding_transcript_variant
rs12497413		chr3:16858763 - 16858763(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
3p24	chr3:16300000-30800000	1 (0/1/0)
Chr 3	chr3:0-198295559	2 (0/2/0)
3p24-p26	chr3:0-30800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr3:16802651..17090594 View in gBrowse