Gene Report

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Basic Info

Approved Symbol	UPK3B
Symbol Alias	MGC10902, p35, UPIIIb, FLJ32198
Approved Name	uroplakin 3B
Name Alias	uroplakin IIIb
Location	7q11.2
Position	chr7:76510428-76516521, 1
External Links	HGNC: 21444 Entrez Gene: 80761 Ensembl: ENSG00000243566 UCSC: uc003ufo.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McQuillin, A.,2011		Gene related CNV occurred in two or more cases but not in controls.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0010629	negative regulation of gene expression	biological process	IMP[18776082]	12

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
UPK3B	UPK1B	NO	in vitro;in vivo	12446744

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_McQuillin[2011]_2	chr7:75975221-76052734 (NCBI Build 36 (hg18))	77514

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q11.2	chr7:62100000-77900000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:76510428..76516521 View in gBrowse