Gene Report

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Basic Info

Approved Symbol	DGKB
Previous Symbol	DAGK2
Symbol Alias	KIAA0718, DGK, DGK-BETA
Approved Name	diacylglycerol kinase, beta 90kDa
Previous Name	diacylglycerol kinase, beta (90kD)
Location	7p21.2
Position	chr7:14145049-14974777, -1
External Links	HGNC: 2850 Entrez Gene: 1607 Ensembl: ENSG00000136267 UCSC: uc003ssz.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		DGKB has been implicated in brain diseases and murine model of Alzheimerâ€™s disease.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005509	calcium ion binding	molecular function	IEA	50

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005524	ATP binding	molecular function	IEA	118
GO:0035556	intracellular signal transduction	biological process	IEA	38
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	biological process	IEA	7
GO:0004143	diacylglycerol kinase activity	molecular function	IEA	3
GO:0030168	platelet activation	biological process	TAS	22
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0007596	blood coagulation	biological process	TAS	44
GO:0016310	phosphorylation	biological process	IEA	9
GO:0003951	NAD+ kinase activity	molecular function	IEA	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04070	Phosphatidylinositol signaling system	16

ID	Name	No. of Genes in BDgene	Brief Description
hsa00564	Glycerophospholipid metabolism	7
hsa00561	Glycerolipid metabolism	6

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p22.2-p21.1	chr7:2800000-20900000	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:14145049..14974777 View in gBrowse