Gene Report

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Basic Info

Approved Symbol	CNNM4
Previous Symbol	ACDP4
Symbol Alias	KIAA1592
Approved Name	cyclin and CBS domain divalent metal cation transport mediator 4
Previous Name	cyclin M4
Location	2q11.2
Position	chr2:96760902-96811891, 1
External Links	HGNC: 105 Entrez Gene: 26504 Ensembl: ENSG00000158158 UCSC: uc002swx.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Byrne, E. M., 2014	SNP: rs6746896	The gene CNNM4 on chromosome 2 is located downstream of the genome-wide significant SNP (rs6746896, BPD P=2.45*10-9) and ranks second among the extended circadian gene list for association with BPD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0006811	ion transport	biological process	IEA	18
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031214	biomineral tissue development	biological process	IEA	2
GO:0007601	visual perception	biological process	IEA	15
GO:0050896	response to stimulus	biological process	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6746896	chr2:96745212 - 96745212(1)		5(3/0/2)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p16.1-q11.2	chr2:54700000-102100000	1 (1/0/0)
2q11	chr2:93900000-102100000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:96760902..96811891 View in gBrowse