Gene Report

Basic Info
Approved Symbol CACNB2
Previous Symbol MYSB, CACNLB2
Approved Name calcium channel, voltage-dependent, beta 2 subunit
Location 10p12
Position chr10:18140677-18541869, 1
External Links HGNC: 1402
Entrez Gene: 783
Ensembl: ENSG00000165995
UCSC: uc001ipr.2
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 SNP: rs2799573 Significant association was observed in cross-disorder analysis. Positive Comment on Study
Lee, M. T.,2011 SNP: rs11013860 No significant associations were detected in BPI patients. Negative Comment on Study
Jan, W. C., 2014 SNP: rs11013860 Weak associations for CACNB2 (rs11013860) genes were observed. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 16)

GO terms by PBA (count: 6)

GO terms by database search (count: 10)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 3)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr10:18140677..18541869 View in gBrowse
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