Gene Report

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Basic Info

Approved Symbol	GRIN3A
Symbol Alias	GluN3A
Approved Name	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Location	9q31.1
Position	chr9:101569353-101738580, -1
External Links	HGNC: 16767 Entrez Gene: 116443 Ensembl: ENSG00000198785 UCSC: uc004bbp.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Takata, A., 2013	SNP: rs149729514	We did not observe significant association between this gene and bipolar disorder. The identified SNVs, particularly the GRIN3A R480G variant, are good candidates for further replication studies and functional evaluation.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006816	calcium ion transport	biological process	ISS	14
GO:0045211	postsynaptic membrane	cellular component	IBA	68
GO:0016020	membrane	cellular component	IDA[17997397]	137
GO:0005262	calcium channel activity	molecular function	IEA	9
GO:0016021	integral component of membrane	cellular component	NAS[11880201]	219
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IBA	12
GO:0045202	synapse	cellular component	IDA[17658481]	29

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045471	response to ethanol	biological process	IDA[17502428]	24
GO:0030054	cell junction	cellular component	IEA	88
GO:0035235	ionotropic glutamate receptor signaling pathway	biological process	IBA	13
GO:0043025	neuronal cell body	cellular component	IDA[17658481]	50
GO:0016594	glycine binding	molecular function	IDA[17320117]	6
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity	molecular function	IDA[17502428]; ISS	5
GO:0042165	neurotransmitter binding	molecular function	IEA	2
GO:0016358	dendrite development	biological process	IEA	8
GO:0060134	prepulse inhibition	biological process	IEA	8
GO:0051721	protein phosphatase 2A binding	molecular function	ISS	2
GO:0048511	rhythmic process	biological process	IEA	7
GO:0005515	protein binding	molecular function	IPI[17658481]	563
GO:0070588	calcium ion transmembrane transport	biological process	IEA	24
GO:0034220	ion transmembrane transport	biological process	IBA	50
GO:0030425	dendrite	cellular component	IBA	65
GO:0042802	identical protein binding	molecular function	IPI[17997397]	44
GO:0035249	synaptic transmission, glutamatergic	biological process	IBA	14
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	cellular component	IDA[17997397]	5
GO:0043005	neuron projection	cellular component	IDA[17658481]	38

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GRIN3A	GRIN1	YES	in vitro;in vivo	11588171 , 9620802 , 11160393
GRIN3A	DLG4	NO	in vitro;in vivo;yeast 2-hybrid	7569905
GRIN3A	DYNLL1	NO	in vitro	14760703
GRIN3A	GRIN2B	YES	in vivo	12391275

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4743473	chr9:101590292 - 101590292(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs149729514	chr9:101670974 - 101670974(1)	missense_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs11788456		chr9:101585868 - 101585868(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
9q21-32	chr9:65000000-114900000	1 (0/1/0)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q31	chr9:99800000-112100000	6 (0/4/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
23237318	The GRIN3A R480G variant (rs149729514) was most significantly associated with schizophrenia. The identified SNVs, particularly the GRIN3A R480G variant, are good candidates for further replication studies and functional evaluation.	Positive

Reference	ID in SZGene	Result Category
18075478	661	Negative
19665356	661	Negative

Gene relationship with MDD

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Region: chr9:101569353..101738580 View in gBrowse