Gene Report

Basic Info
Approved Symbol CHRNB3
Approved Name cholinergic receptor, nicotinic, beta 3 (neuronal)
Previous Name cholinergic receptor, nicotinic, beta polypeptide 3
Name Alias acetylcholine receptor, nicotinic, beta 3 (neuronal)
Location 8p11.21
Position chr8:42697376-42737407, 1
External Links HGNC: 1963
Entrez Gene: 1142
Ensembl: ENSG00000147432
UCSC: uc003xpi.1
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 4 SNP typed, Median D'=1, Median r<sup>2</sup> =0.23, 1 LD blocks, 0.88 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. Negative Comment on Study
Hartz, S. M.,2011 SNP: rs4952, rs4953, rs6474413 Our results suggest that (i) bipolar disorder does not modify the association between nicotine dependence and nicotinic receptor subunit genes, and (ii) variants in CHRNB3/CHRNA6 are independently associated with bipolar disorder. Positive Comment on Study
Shi, J., 2007 SNP: rs11783289, rs7004381, rs7017612 no evidence of interaction among these 19 cholinergic genes was found by Allelic Association, Haploview Tests, FITF analysis and FDR correction Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 18)

GO terms by PBA (count: 5)

GO terms by database search (count: 13)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 19)

Literature-origin SNPs (count: 11)

LD-proxies (count: 8)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr8:42697376..42737407 View in gBrowse
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