Gene Report

Basic Info
Approved Symbol PIK3R1
Symbol Alias GRB1, p85-ALPHA, p85
Approved Name phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Location 5q13.1
Position chr5:68215720-68301821, 1
External Links HGNC: 8979
Entrez Gene: 5295
Ensembl: ENSG00000145675
UCSC: uc003jva.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Drago, A., 2016 Freq(Significant SNPs/total SNPs%)=0.13. Encodes for a subunit of Phosphatidylinositol 3-kinase enzyme which is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 65)

GO terms by PBA (count: 6)

GO terms by database search (count: 59)

Gene related KEGG pathways (count: 27)

Gene related BioCarta pathways (count: 47)

BioCarta pathways by PBA (count: 1)

BioCarta pathways by database search (count: 46)

Gene related interactors from protein-protein interactions data in HPRD (count: 122)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr5:68215720..68301821 View in gBrowse
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