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Gene Report
Basic information | Related studies | Functional annotation | Related other genetic factors | Overlap with SZ and MDD | ADD to My Gene Set | Comment on Gene | View All Comments on Gene |
Approved Symbol | PIK3R1 |
---|---|
Symbol Alias | GRB1, p85-ALPHA, p85 |
Approved Name | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
Location | 5q13.1 |
Position | chr5:68215720-68301821, 1 |
External Links |
HGNC: 8979 Entrez Gene: 5295 Ensembl: ENSG00000145675 UCSC: uc003jva.3 |
No. of Studies | 1 (Positive: 1; Negative: 0; trend: 0) |
Overlap with SZ? | YES |
Overlap with MDD? | YES |
Reference | Tested Markers | Statistical Values/Author Comments | Result Category | Comment on Study |
---|---|---|---|---|
Drago, A., 2016 | Freq(Significant SNPs/total SNPs%)=0.13. Encodes for a subunit of Phosphatidylinositol 3-kinase enzyme which is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. | Positive | Comment on Study |
GO terms by PBA (count: 6)

ID | Name | Type | Evidence[PMID] | No. of Genes in BDgene |
---|---|---|---|---|
GO:0005634 | nucleus | cellular component | ISS | 283 |
GO:0005159 | insulin-like growth factor receptor binding | molecular function | IPI[7541045] | 5 |
GO:0005886 | plasma membrane | cellular component | TAS | 360 |
GO:0016020 | membrane | cellular component | IDA[19946888] | 137 |
GO:0005158 | insulin receptor binding | molecular function | IPI[7537849] | 5 |
GO:0045087 | innate immune response | biological process | TAS | 49 |
GO terms by database search (count: 59)

KEGG pathways by PBA (count: 6)

ID | Name | No. of Genes in BDgene | Brief Description |
---|---|---|---|
hsa05214 | Glioma | 9 | |
hsa04070 | Phosphatidylinositol signaling system | 16 | |
hsa05221 | Acute myeloid leukemia | 7 | |
hsa05222 | Small cell lung cancer | 8 | |
hsa04210 | Apoptosis | 12 | |
hsa04510 | Focal adhesion | 22 |
KEGG pathways by database search (count: 21)

BioCarta pathways by PBA (count: 1)

ID | Name | No. of Genes in BDgene | Brief Description |
---|---|---|---|
badPathway | Regulation of BAD phosphorylation | 9 |
BioCarta pathways by database search (count: 46)

Region Name | Position | No. of Studies (Positive/Negative/Trend) ![]() |
---|---|---|
Chr 5 | chr5:0-181538259 | 3 (0/2/1) |
5p13.3-q13.3 | chr5:28900000-77600000 | 1 (1/0/0) |
Overlap with SZ from cross-disorder studies (count: 0)
Overlap with SZ from candidate gene intersection analysis (count: 1)

Overlap with MDD from cross-disorder studies (count: 0)
Overlap with MDD from candidate gene intersection analysis (count: 1)

Region: chr5:68215720..68301821 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016