Gene Report

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Basic Info

Approved Symbol	SEMA3D
Symbol Alias	coll-2, Sema-Z2
Approved Name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Location	7q21.11
Position	chr7:84995553-85186855, -1
External Links	HGNC: 10726 Entrez Gene: 223117 Ensembl: ENSG00000153993 UCSC: uc003uic.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kuo, P. H., 2014	SNP: rs10260011	Gene-based P-value (allelic model) =0.0419, P-value (additive model) =0.0368. SEMA3D, with a P-value of less than 0.05 (P= 0.037).	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030154	cell differentiation	biological process	IEA	31
GO:0004872	receptor activity	molecular function	IEA	19
GO:0007399	nervous system development	biological process	IEA	40
GO:0016020	membrane	cellular component	IEA	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005576	extracellular region	cellular component	IEA	97

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04360	Axon guidance	16

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10260011	chr7:85080040 - 85080040(1)	intron_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21	chr7:77900000-98400000	4 (0/2/2)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
20684831	988	Positive

Gene relationship with MDD

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Region: chr7:84995553..85186855 View in gBrowse