Gene Report

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Basic Info

Approved Symbol	NPFFR2
Previous Symbol	GPR74
Symbol Alias	NPFF2, NPGPR
Approved Name	neuropeptide FF receptor 2
Previous Name	G protein-coupled receptor 74
Name Alias	neuropeptide FF 2
Location	4q21
Position	chr4:72031804-72148067, 1
External Links	HGNC: 4525 Entrez Gene: 10886 Ensembl: ENSG00000056291 UCSC: uc003hgg.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs4485795	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008188	neuropeptide receptor activity	molecular function	IBA	5
GO:0005887	integral component of plasma membrane	cellular component	TAS[10079187]	158
GO:0005886	plasma membrane	cellular component	IDA; TAS	360
GO:0007268	synaptic transmission	biological process	IBA	116

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2000479	regulation of cAMP-dependent protein kinase activity	biological process	IEA	1
GO:0007218	neuropeptide signaling pathway	biological process	IBA	18
GO:1901652	response to peptide	biological process	IBA	5
GO:0045761	regulation of adenylate cyclase activity	biological process	IEA	1
GO:0015629	actin cytoskeleton	cellular component	IDA	18
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[10851242]	26
GO:0043408	regulation of MAPK cascade	biological process	IEA	6
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[10079187]	64
GO:0031628	opioid receptor binding	molecular function	IEA	1
GO:0042277	peptide binding	molecular function	IBA	11
GO:0032870	cellular response to hormone stimulus	biological process	IBA	9
GO:0009582	detection of abiotic stimulus	biological process	TAS[10851242]	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NPFFR2	NPFF	NO	in vivo	10851242 , 12609745
NPFFR2	NPY	NO	in vivo	12609745
NPFFR2	HCRT	NO	in vivo	12609745

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4485795	chr4:72057835 - 72057835(1)	intron_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4q13.3	chr4:69400000-75300000	1 (0/1/0)
4q12-q21	chr4:51800000-87100000	1 (0/0/1)
4q12-q13	chr4:51800000-75300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:72031804..72148067 View in gBrowse